Results 51 to 60 of about 132,096,113 (307)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Department of Computer Science newsletter 2022
, 2022 A Newsletter for Friends and Supporters of the Mines Computer Science Department.
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An island based hybrid evolutionary algorithm for optimization [PDF]
, 2008 This is a post-print version of the article - Copyright @ 2008 Springer-VerlagEvolutionary computation has become an important problem solving methodology among the set of search and optimization techniques. Recently, more and more different evolutionary
Yang, S +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
An incremental approach to genetic algorithms based classification [PDF]
, 2005 Incremental learning has been widely addressed in the machine learning literature to cope with learning tasks where the learning environment is ever changing or training samples become available over time. However, most research work explores incremental
Guan, SU, Zhu, F, Zhu, F., Guan, S.-U.
core +1 more source
Word embedding for social sciences: an interdisciplinary survey [PDF]
PeerJ Computer ScienceMachine learning models learn low-dimensional representations from complex high-dimensional data. Not only computer science but also social science has benefited from the advancement of these powerful tools.
Akira Matsui, Emilio Ferrara
doaj +2 more sources
PROBABILISTIC QUANTUM COMPUTER SIMULATOR [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2008 Quantum Computation is a new field in science. It relates to quantum physics and computer science. The concept of quantum computers regarded new theoretical stage due to the fact that working and real quantum computers not exist and in development stage ...
Yusra Mahmood Humadi
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Algorithmic Thinking: The Key for Understanding Computer Science [PDF]
, 2006 We show that algorithmic thinking is a key ability in informatics that can be developed independently from learning programming. For this purpose we use problems that are not easy to solve but have an easily understandable problem definition. A proper visualization of these problems can help to understand the basic concepts connected with algorithms ...
openaire +1 more source