Results 51 to 60 of about 272,600 (304)

Improved approximation algorithms for optimization problems in graphs with superlogarithmic treewidth

, 2003
In this paper we present two novel generic schemes for approximation algorithms for optimization to partial k-trees. Our first scheme yields deterministic polynomialtime algorithms achieving typically an approximation factor of k/ log n, where k
Chlebikova, Janka, Lingas, Andrzej,, Artur Czumaj, Johan Nilsson, Czumaj, Artur, Andrzej Lingas, Czumaj, A, Nilsson, J, Nilsson, Johan, Miroslav Chlebík, Chlebik, Miroslav, Miroslav Chlebik (4461319), Lingas, Andrzej, Janka Chlebíková, Janka Chlebíková (16060964)   +14 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Augmented learning roads for internet routing

, 2014
As the Internet continues to establish itself as a utility, like power, transport or water, it becomes increasingly important to provide an engaging educational experience about its operation for students in related STEM disciplines such as Computer ...
Miller, Alan Henry David, Alan Miller, Colin Allison, Allison, Colin, Oliver, Iain Angus, McCaffery, John Philip, John McCaffery, Iain Oliver   +7 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Machine Learning in P&C Insurance: A Review for Pricing and Reserving

Risks, 2020
In the past 25 years, computer scientists and statisticians developed machine learning algorithms capable of modeling highly nonlinear transformations and interactions of input features.
Christopher Blier-Wong, Hélène Cossette, Luc Lamontagne, Etienne Marceau   +3 more
doaj   +1 more source

Learning from the past with experiment databases

, 2008
Thousands of Machine Learning research papers contain experimental comparisons that usually have been conducted with a single focus of interest, and detailed results are usually lost after publication.
Joaquin Vanschoren, Pfahringer, Bernhard, Bernhard Pfahringer, Geoff Holmes, Geoffrey Holmes, Holmes, Geoff, Vanschoren, Joaquin, Holmes, Geoffrey   +7 more
core   +1 more source

Advancements in Computer Science: From Algorithms to AI

, 2023
Advancements in Computer Science: From Algorithms to ...
Ali Hassan
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Relational implementation of simple parallel evolutionary algorithms

, 2006
Randomized search heuristics, among them evolutionary algorithms, are applied to problems whose structure is not well understood, as well as to hard problems in combinatorial optimization to get near-optimal solutions.
Berghammer, R., Kehden, B., Rudolf Berghammer, Britta Kehden, Neumann, F., Frank Neumann   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source