Results 171 to 180 of about 75,003 (261)

Mirabegron and Intradetrusor Onabotulinumtoxina for Overactive Bladder in Parkinson's Disease: A Systematic Review and Meta‐Analysis

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Objective To synthesize the evidence on the efficacy and safety of mirabegron and intradetrusor onabotulinumtoxinA (BoNT‐A) as separate interventions for overactive bladder (OAB) in Parkinson's disease (PD). Methods A systematic review and meta‐analysis with parallel synthesis of two distinct interventions was conducted of randomized and ...
Hussain Arshad   +4 more
wiley   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

Evidence for dispersal personality in the guppy across ecological conditions, with a minor effect of relative brain size

open access: yesOikos, EarlyView.
Individuals that disperse typically exhibit specific phenotypical traits that facilitate dispersal and settlement success, known as ‘dispersal syndromes'. Consequentially, characterizing dispersers is crucial to understand other processes such as metapopulation dynamics and biological invasions.
Gilles De Meester   +6 more
wiley   +1 more source

Habitat fragmentation and amount drive within‐species variation in dispersal kernels and limit transferability across landscapes

open access: yesOikos, EarlyView.
Dispersal is a key ecological trait that ensures connectivity, gene flow, and range dynamics, yet empirical information about how dispersal distances vary within species remains scarce. Many studies, investigating for instance connectivity conservation, use typical species‐specific dispersal kernels without accounting for the fact that these kernels ...
Jette Wolff   +5 more
wiley   +1 more source

Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Intravenous lidocaine therapy (IVLT) is often used in perioperative multimodal analgesia due to its analgesic, anti‐hyperalgesic, and anti‐inflammatory effects. In adults, IVLT doses of 1–2 mg/kg/h produce plasma concentrations of 1–2 μg/mL, within the presumed therapeutic range of 1–5 μg/mL.
McKenna Postles   +3 more
wiley   +1 more source

Alien hand syndrome: a neurological disorder of will

open access: yesSchweizer Archiv für Neurologie und Psychiatrie, 2010
openaire   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

open access: yesThe Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan   +9 more
wiley   +1 more source

Asymmetric Upper Limb Dysfunction Demonstrated at the Bedside: A Phenomenology Video

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Gero Lueg   +4 more
wiley   +1 more source

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