Results 121 to 130 of about 19,474 (263)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Invasive Alien Species of European Union Concern: A Systematic Review of High-Priority Pathogens in 22 Species in a One Health Framework. [PDF]

Animals (Basel)
Spadotto L, Centelleghe C, Ceolotto L, Mazzariol S, Cavicchioli L.   +4 more
europepmc   +1 more source

Introduced and invasive alien species of Antarctica and the Southern Ocean Islands. [PDF]

Sci Data, 2023
Leihy RI, Peake L, Clarke DA, Chown SL, McGeoch MA.   +4 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Meta-analysis reveals negative but highly variable impacts of invasive alien species across terrestrial insect orders. [PDF]

Nat Commun
Skinner GLV, Cooke R, Roy HE, Isaac NJB, Outhwaite CL, Rodger J, Millard J.   +6 more
europepmc   +1 more source

Precipitation pattern alters the effects of nitrogen deposition on the growth of alien species Robinia pseudoacacia. [PDF]

Heliyon, 2023
Wang X, Guo X, Ding W, Du N, Guo W, Pang J.   +5 more
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Monitoring Alien Species Diversity in Ballast Water Based on Environmental DNA Metabarcoding. [PDF]

Ecol Evol
Li H, Jia H, Peng J, Peng X, Ren Z, Zhang H.   +5 more
europepmc   +1 more source

Cumulative Negative Impacts of Invasive Alien Species on Marine Ecosystems of the Aegean Sea. [PDF]

Biology (Basel), 2023
Tsirintanis K, Sini M, Ragkousis M, Zenetos A, Katsanevakis S.   +4 more
europepmc   +1 more source