Results 181 to 190 of about 4,210,741 (299)

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

When the Evidence Points to the Non-Invasive Nature of an Allegedly Invasive Alien Species: The Case of the Aoudad in Mainland Spain. [PDF]

Animals (Basel)
Cassinello J, Albanell E, Eguía S, Roverso A, San Miguel A, Bartolomé J.   +5 more
europepmc   +1 more source

Invasive alien plants are phylogenetically distinct from other alien species across spatial and taxonomic scales in China. [PDF]

Front Plant Sci, 2023
Banerjee AK, Tan F, Feng H, Liang X, Wang J, Yin M, Peng H, Lin Y, Zhang N, Huang Y.   +9 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Global Initiative for the Risk Assessment Working Group of Invasive Alien Species. [PDF]

Biology (Basel)
Pan X.
europepmc   +1 more source

How do urbanization and alien species affect the plant taxonomic, functional, and phylogenetic diversity in different types of urban green areas? [PDF]

Environ Sci Pollut Res Int, 2023
Dylewski Ł, Banaszak-Cibicka W, Maćkowiak Ł, Dyderski MK.   +3 more
europepmc   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Variable Importance Measures Suggest Paramount Influence of Human Economics on Alien-Species Introductions. [PDF]

Ecol Evol
Arranz I, Nally RM, García-Berthou E.
europepmc   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

The Invasive Mechanism and Impact of <i>Arundo donax,</i> One of the World's 100 Worst Invasive Alien Species. [PDF]

Plants (Basel)
Kato-Noguchi H, Kato M.
europepmc   +1 more source