Results 131 to 140 of about 2,727,008 (278)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
SensorsThe rapid development of active safety systems in the automotive industry and research in autonomous driving requires reliable, high-precision sensors that provide rich information about the surrounding environment and the behaviour of other road users ...
Rafał Michał Burza
doaj +1 more source
Journal of Intelligent Systems, 2019 Machine translation (MT) from English to foreign languages is a fast developing area of research, and various techniques of translation are discussed in the literature. However, translation from English to Malayalam, a Dravidian language, is still in the
Sebastian Mary Priya, Kumar G. Santhosh
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
, 1944 Contents [start-list] *A. Introduction *B. Scales *C. Slide Rules *D. Three-rowed Determinants *E. Alignment Charts *F. The Quadratic and the Reduced Cubic *G. Parallel Scales *H. Mechanical Details *I. The Transformation Theory *J. Projective Transformations *K. The Straight Line *L. Conics *M. The Problem of the Rectangular Page *N.
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Aligners: Decoupling LLMs and Alignment
Findings of the Association for Computational Linguistics: EMNLP 2024Large Language Models (LLMs) need to be aligned with human expectations to ensure their safety and utility in most applications. Alignment is challenging, costly, and needs to be repeated for every LLM and alignment criterion. We propose to decouple LLMs and alignment by training aligner models that can be used to align any LLM for a given criteria on ...
Ngweta, Lilian +5 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Journal of Experimental OrthopaedicsPurpose The purpose of this study was to assess the differences in lower limb global alignment and anatomical parameters of coronal whole‐leg radiographs, which were generally used in preoperative planning for high tibial osteotomy (HTO), according to ...
Tomoaki Kamiya +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source