Results 91 to 100 of about 443,032 (268)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Human-in-the-Loop Optimization of the Stiffness and Alignment of a Prosthetic Foot to Reduce the Metabolic Cost of Walking

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Improper tuning of prosthetic foot properties to the individual user limits the efficacy of current state-of-the-art prosthetic feet in terms of walking economy.
Thijs Tankink, Han Houdijk, Johnnidel Tabucol, Marco Leopaldi, Juha M. Hijmans, Raffaella Carloni   +5 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Automated spectrometer alignment via machine learning

Journal of Synchrotron Radiation
During beam time at a research facility, alignment and optimization of instrumentation, such as spectrometers, is a time-intensive task and often needs to be performed multiple times throughout the operation of an experiment.
Peter Feuer-Forson, Gregor Hartmann, Rolf Mitzner, Peter Baumgärtel, Christian Weniger, Marcus Agåker, David Meier, Phillipe Wernet, Jens Viefhaus   +8 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

School and Teacher Information, Communication and Technology (ICT) readiness across 57 countries: The alignment optimization method. [PDF]

Educ Inf Technol (Dordr), 2023
Wu R, Yang W, Rifenbark G, Wu Q.
europepmc   +1 more source

Analysis and design optimization of the 1.2m X-ray telescope, volume 1 [PDF]

An image space analysis and optimization and a performance analysis of the telescope assembly in the presence of various alignment errors are reported.
Korsch, D.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Capture the high-efficiency non-fullerene ternary organic solar cells formula by machine-learning-assisted energy-level alignment optimization. [PDF]

Patterns (N Y), 2021
Hao T, Leng S, Yang Y, Zhong W, Zhang M, Zhu L, Song J, Xu J, Zhou G, Zou Y, Zhang Y, Liu F.   +11 more
europepmc   +1 more source

Automatic Texture Alignment by Optimization Method

Microscopy and Microanalysis
Abstract Microstructure analysis via electron backscatter diffraction has become an indispensable tool in materials science and engineering. In order to interpret or predict the anisotropy in crystalline materials, the texture is assessed, e.g. via pole figure diagrams.
Alois C Ott, Irmgard Weißensteiner, Aurel R Arnoldt, Johannes A Österreicher, Nikolaus P Papenberg   +4 more
openaire   +2 more sources