Results 71 to 80 of about 2,590,839 (306)
Optimal spanners for axis-aligned rectangles
Computational Geometry, 2005 Netherlands’ Organization for Scientific ...
Tetsuo Asano +6 more
openaire +10 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Urban Rail Transit, 2019 Owing to wide-ranging searches (there are various alignments between two points) as well as complex and nonlinear cost functions and a variety of geometric constraints, the problem of optimal railway alignment is classified as a complex problem.
Benyamin Ghoreishi +2 more
doaj +1 more source
Optimal Alignment of Temporal Knowledge Bases
, 2023 Answering temporal CQs over temporalized Description Logic knowledge bases (TKB) is a main technique to realize ontology-based situation recognition. In case the collected data in such a knowledge base is inaccurate, important query answers can be missed.
Oliver Fernandez-Gil +3 more
openaire +5 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Protein alignment HW/SW optimizations [PDF]
2012 19th IEEE International Conference on Electronics, Circuits, and Systems (ICECS 2012), 2012 Biosequence alignment recently received an amazing support from both commodity and dedicated hardware platforms. The limitless requirements of this application motivate the search for improved implementations to boost processing time and capabilities. We propose an unprecedented hardware improvement to the classic Smith-Waterman (S-W) algorithm based ...
URGESE, GIANVITO +5 more
openaire +3 more sources
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Aligned Multi Objective Optimization
CoRRTo date, the multi-objective optimization literature has mainly focused on conflicting objectives, studying the Pareto front, or requiring users to balance tradeoffs. Yet, in machine learning practice, there are many scenarios where such conflict does not take place.
Efroni, Yonathan +6 more
openaire +4 more sources
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source