Results 121 to 130 of about 443,032 (268)

Optimal Sequence Alignment using A*

, 2023
Sequence alignment is the task of finding similarities between sequences. It has been a central building block in molecular biology since DNA, RNA and protein sequences were first obtained half a century ago. Sequence alignment is applied to research and medicine, with applications in evolutionary biology, genome assembly, oncology and many others. The
openaire   +3 more sources

Weak-to-Strong Honesty Alignment via Group-Relative Policy Optimization

Mathematics
Ensuring that Large Language Models align with human values of honesty is a critical challenge, particularly due to the scarcity of labeled data for distinguishing known versus unknown knowledge boundaries.
Jie Zhang, Yunfan Xie, Wen Zou
doaj   +1 more source

Synergistic Interface Energy Band Alignment Optimization and Defect Passivation toward Efficient and Simple-Structured Perovskite Solar Cell. [PDF]

Adv Sci (Weinh), 2020
Huang L, Zhang D, Bu S, Peng R, Wei Q, Ge Z.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Machine learning based crystal collimator alignment optimization

Physical Review Accelerators and Beams
In the CERN Large Hadron Collider (LHC), bent crystals are used to efficiently deflect beam halo particles toward secondary collimators used as absorbers.
Gianmarco Ricci, Marco D’Andrea, Mario Di Castro, Eloise Matheson, Daniele Mirarchi, Andrea Mostacci, Stefano Redaelli   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

KegAlign: optimizing pairwise alignments with diagonal partitioning

Genome Biology
Abstract Advances in sequencing and assembly allow the creation of thousands of genome assemblies. However, producing multiple alignments required for their analysis lags behind due to the time-consuming process of pairwise alignment, typically performed by the slow but sensitive tool lastZ. Here, we develop KegAlign, an optimized GPU-
A. Burak Gulhan, Richard Burhans, Robert Harris, Mahmut Kandemir, Maximilian Haeussler, Anton Nekrutenko   +5 more
openaire   +2 more sources

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source