Results 121 to 130 of about 2,590,839 (306)
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Transportation Research Interdisciplinary PerspectivesAs urban transportation evolves, shared e-mobility is increasingly recognized as a socio-technical system shaping urban equity, social inclusion, and mobility behaviour.
Yue Ding +3 more
doaj +1 more source
Align-Pro: A Principled Approach to Prompt Optimization for LLM Alignment
Proceedings of the AAAI Conference on Artificial IntelligenceThe alignment of large language models (LLMs) with human values is critical as these models become increasingly integrated into various societal and decision-making processes. Traditional methods, such as reinforcement learning from human feedback (RLHF), achieve alignment by fine-tuning model parameters, but these approaches are often computationally ...
Prashant Trivedi +5 more
openaire +3 more sources
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Weak-to-Strong Honesty Alignment via Group-Relative Policy Optimization
MathematicsEnsuring that Large Language Models align with human values of honesty is a critical challenge, particularly due to the scarcity of labeled data for distinguishing known versus unknown knowledge boundaries.
Jie Zhang, Yunfan Xie, Wen Zou
doaj +1 more source
Simple Optimizers for Convex Aligned Multi-Objective Optimization
CoRRIt is widely recognized in modern machine learning practice that access to a diverse set of tasks can enhance performance across those tasks. This observation suggests that, unlike in general multi-objective optimization, the objectives in many real-world settings may not be inherently conflicting.
Ben Kretzu +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Cross-social-network user alignment research based on multi-dimensional user features
Systems Science & Control EngineeringAccurately aligning the same users on different flat social networks to merge user information and create more nuanced user profiles is critical. However, the current research in this area faces challenges related to low efficiency and inadequate ...
Tao Zhao +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source