Results 71 to 80 of about 6,808 (254)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Le contrôle de l’acidose ruminale latente

INRAE Productions Animales, 2006
Le principal critère d’évaluation de l’acidose du rumen est le pH moyen mesuré pendant plusieurs heures après le repas. D’autres critères ont été proposés, cependant ils restent très corrélés au précédent et ne fournissent pas d’information plus ...
D. SAUVANT, S. GIGER-REVERDIN, F. MESCHY
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

« Aliments fonctionnels et lipides »

Oléagineux, Corps gras, Lipides, 2001
Proposer un dossier sur les aliments fonctionnels dits « aliments-santé » se justifie doublement, d’une part, parce que l’année 2001 est sans conteste marquée par le développement confirmé de ces produits et, d’autre part, parce que les matières grasses (
Rossignol-Castera Anne
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Contribution des laits de croissance et des compléments à l’adéquation nutritionnelle de régimes alimentaires d’enfants en bas âge. [Role of Young Child Formulae and Supplements to Ensure Nutritional Adequacy in Young Children [1]

Nutrition & Santé, 2017
Introduction. L’autorité européenne de sécurité des aliments (AESA) assure que les laits de croissance « n’apportent pas de valeur supplémentaire à une alimentation équilibrée pour répondre aux besoins nutritionnels des enfants en bas âge ».
Chloé M.C. BROUZES, Florent VIEUX, Matthieu MAILLOT, André BRIEND, Régis HANKARD, Anne LLUCH, Nicole DARMON   +6 more
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

High-throughput characterization of the effect of sodium chloride and potassium chloride on 31 lactic acid bacteria and their co-cultures

Frontiers in Microbiology
Salt (NaCl) is associated with a risk of hypertension and the development of coronary heart disease, so its consumption should be limited. However, salt plays a key role in the quality and safety of food by controlling undesirable microorganisms.
Amadou Ndiaye, Amadou Ndiaye, Amadou Ndiaye, Ismail Fliss, Ismail Fliss, Marie Filteau, Marie Filteau, Marie Filteau   +7 more
doaj   +1 more source