Results 71 to 80 of about 32,282 (298)
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration
Angewandte Chemie, EarlyView.The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti +9 more
wiley +2 more sources
Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
Molecules, 2009 The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
Mehdi Ghandi, Abuzar Taheri
doaj +1 more source
Advanced Science, EarlyView.This study establishes an interpretable machine learning framework that disentangles the intrinsic molecular efficacy of passivators from experimental platform effects—enabling unbiased, high‐throughput discovery of effective perovskite surface modifiers.
Jing Zhang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Red‐emissive carbon dots (R‐CDs) exhibiting aggregation‐induced emission (AIE) and aggregation‐caused quenching (ACQ) effects are synthesized from citric acid and urea. They display weak blue fluorescence in water but strong red emission in DMF due to aggregation.
Jiafeng Wan +11 more
wiley +2 more sources
Orbital: The Electronic Journal of Chemistry, 2018 A straightforward, rapid, and efficient protocol for the N-tert-butoxy carbonyl (N-Boc) protection of amines (aromatic, aliphatic) using sulfated tin oxide catalyst is illustrated.
J. K. Prashanth Kumar +5 more
doaj +3 more sources
Neue Methode zur reduktiven Desaminierung primärer aliphatischer Amine
CHIMIA, 1988 A new method for reductive deamination of primary aliphatic amines via tributyltin hydride reduction of aromatic imidoyl chlorides is reported. Good yields of hydrocarbons were obtained from benzylamines and cyclohexylamine, but not from 1-alkylamines.
Thomas Wirth, Christoph Rüchardt
doaj +1 more source
Hydrothermal Humification of Biomass for Circular Carbon Management in Sustainable Agro‐Ecosystems
Advanced Science, EarlyView.This article provides a comprehensive overview of biomass hydrothermal humification for building sustainable agro‐ecosystems. It examines the chemical transformation mechanisms and the functional benefits of the produced humic acids in soil remediation.
Ziyun Liu +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Enantioselective aminoarylation of ortho‐allyl anilines is achieved under mild conditions. Key to success is the electrostatically‐directed nature of the key aminopalladation step, achieved by using the sulfonated chiral ligand sSPhos on palladium. A detailed study of electronic trends allows tuning of the sulfonamide protecting group to enable good ...
Max Kadarauch +4 more
wiley +2 more sources
Green Processing and SynthesisRhinsitu/mesSiO2 was prepared in one step by incorporating rhodium units onto the silica during the sol–gel process. It was revealed as an excellent active and selective catalyst for the hydrogenation of aromatic, heteroaromatic, aliphatic nitriles, and ...
Ajjou Abdelaziz Nait +2 more
doaj +1 more source