Results 111 to 120 of about 35,022 (246)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ...
Shrina Patel, Brad Graham, Kaci Reaves, Mya Phelps   +3 more
wiley   +1 more source

Cellular Dynamics and Dentine Bridge Formation Following Direct Pulp Capping With MTA and Biodentine in a Murine Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim Formation of a mineralized dentine bridge is the hallmark of successful direct pulp capping (DPC). Mineral trioxide aggregate (MTA) and Biodentine are widely used capping materials, but in vivo evidence comparing their regenerative potential remains inconclusive. This study used a controlled murine model to compare dentine bridge formation
Amnah Sajdeya, Joshua Milgram, Nurit Kot‐Limon, Itzhak Abramovitz, Amnon Sharir   +4 more
wiley   +1 more source

Early life history of the Korean seahorse, Hippocampus haema: Evidence for direct settlement and ontogenetic shifts in snout morphology

Journal of Fish Biology, EarlyView.
Abstract Early life‐history traits of seahorses are closely linked to juvenile survival, dispersal potential and the onset of substrate attachment; however, detailed stage‐resolved descriptions remain limited for many Hippocampus species. This study examined reproductive behaviour and early ontogenetic development of the Korean seahorse, Hippocampus ...
Jaehwan Juan Lee, Jin‐Koo Kim
wiley   +1 more source

Developmental stage ordering yields greater cranial mineralization sequence resolution than embryo size or days since oviposition: A case study using the gekkotan Eublepharis macularius (Blyth, 1854)

Journal of Anatomy, EarlyView.
We employ a set of leopard gecko embryos for which size, day of development, and developmental stage are known to assess which timetable accords with the greatest resolution of cranial mineralization events. Developmental staging yielded the best outcome. Abstract Mineralization sequences of cranial elements (often referred to as ossification sequences)
Patrick A. D. Wise, Aaron H. Griffing, Anthony P. Russell   +2 more
wiley   +1 more source

Antifungal and Antivirulence Activity of Alizarin against <i>Candida dubliniensis</i>. [PDF]

ACS Infect Dis
Arumugam G, Muniasamy S, Nagai de Lima PM, Barcick U, Zelanis A, Campitelli Barros BCS, Castro Pedroso LL, Borges BM, Preite NW, Loures FV, Junqueira JC.   +10 more
europepmc   +1 more source

Feldspar Albitization With Implications for Reservoir Quality Evolution of Eocene Turbidite Sandstones in Offshore Espírito Santo Basin, Eastern Brazil

Journal of Petroleum Geology, EarlyView.
ABSTRACT The diagenetic albitization of plagioclase and K‐feldspar grains is a transformative process that significantly alters sandstone's detrital composition and formation water chemistry, impacting reservoir quality. In this study, Eocene turbidite sandstones from the offshore Espírito Santo Basin, Brazil, were investigated to elucidate the role of
Eveline E. Zambonato, Luiz F. De Ros, Howri Mansurbeg   +2 more
wiley   +1 more source

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source