The Effective Treatment of Purpurin on Inflammation and Adjuvant-Induced Arthritis [PDF]
Molecules, 2023 Rubia cordifolia L. (Rubiaceae), one of the traditional anti-rheumatic herbal medicines in China, has been used to treat rheumatoid arthritis (RA) since ancient times.
Ping Yan, Shen Caihong
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On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin [PDF]
Antioxidants, 2023 Purpurin is a major anthraquinone present in the roots of Rubia cordifolia (madder). Purpurin is known to activate Nrf2 (Nuclear transcription factor erythroid 2-related factor 2) EpRE (electrophile responsive element) mediated gene expression as a ...
Qiuhui Ren +2 more
exaly +4 more sources
Purpurin suppresses atopic dermatitis via TNF-α/IFN-γ-induced inflammation in HaCaT cells
International Journal of Immunopathology and Pharmacology, 2022 Objective We investigated whether purpurin inhibits various pathways of inflammation leading to atopic dermatitis. Introduction 1,2,4-Trihydroxyanthraquinone, commonly called purpurin, is an anthraquinone that is a naturally occurring red/yellow dye ...
Ok-Kyoung Kwon +2 more
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Purpurin Rescues Contrast-Induced Acute Rat Kidney Injury via Inducing Autophagy and Inhibiting Apoptosis [PDF]
PharmaceuticalsObjectives: Contrast-induced acute kidney injury (CIAKI) is a major cause of hospital-acquired renal injury, and strategies for its treatment are currently lacking.
Kangxu He +5 more
doaj +2 more sources
Copper-mediated DNA damage caused by purpurin, a natural anthraquinone [PDF]
Genes and Environment, 2022 Background Purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment, has historically been used as a textile dye. However, purpurin induced urinary bladder tumors in rats, and displayed a mutagenic activity in assay using ...
Hatasu Kobayashi +7 more
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Anthraquinone Production from Cell and Organ Cultures of Rubia Species: An Overview [PDF]
Metabolites, 2022 The Rubia genus includes major groups of medicinal plants such as Rubia cordifolia, Rubia tinctorum, and Rubia akane. They contain anthraquinones (AQs), particularly alizarin and purpurin, which have pharmacological effects that are anti-inflammatory ...
Hosakatte Niranjana Murthy +3 more
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Effects of geographical, soil and climatic factors on the two marker secondary metabolites contents in the roots of Rubia cordifolia L. [PDF]
Frontiers in Plant ScienceThe growth and quality of medicinal plants depend heavily on environmental variables. The quality of Rubia cordifolia, an important medicinal plant, is determined by the two main secondary metabolites of the root, purpurin and mollugin.
Yanlin Wang +20 more
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Dynamic analysis of growth characteristics, secondary metabolites accumulation, and an in-depth understanding of anthraquinones biosynthesis in Rubia cordifolia Linn. [PDF]
Frontiers in Plant ScienceRubia cordifolia is a well-known plant used in oriental medicine plant, and is also serves as the primary traditional source of plant red dyestuffs. With the current depletion of natural resources of R.
Conglong Lian +16 more
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A purpurin-based metalloimmunostimulant amplifies ROS and modulates STING/TNF-α axis to potentiate melanoma immunotherapy [PDF]
Materials Today BioThe low infiltration of pro-inflammatory immune cells and the sustained activation of multiple immunosuppressive signaling pathways in melanoma significantly limit the efficacy of clinical immunotherapy. Therefore, developing an effective immunostimulant
Xiaoxin Yang +7 more
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Anthraquinones Inhibit Insulin Amyloidosis in Crowded Environments [PDF]
MoleculesNatural anthraquinones possess a wide range of biological activities, including antibacterial, antiviral, antitumor, and antioxidant effects. However, studies on their ability to inhibit amyloid protein aggregation remain relatively limited.
Jiaxing Zhang +5 more
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