Results 1 to 10 of about 1,042 (139)

On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin [PDF]

Antioxidants, 2023
Purpurin is a major anthraquinone present in the roots of Rubia cordifolia (madder). Purpurin is known to activate Nrf2 (Nuclear transcription factor erythroid 2-related factor 2) EpRE (electrophile responsive element) mediated gene expression as a ...
Qiuhui Ren, Wouter Bakker, Sebastiaan Wesseling, Hans Bouwmeester, Ivonne M. C. M. Rietjens   +4 more
doaj   +2 more sources

Purpurin Rescues Contrast-Induced Acute Rat Kidney Injury via Inducing Autophagy and Inhibiting Apoptosis [PDF]

Pharmaceuticals
Objectives: Contrast-induced acute kidney injury (CIAKI) is a major cause of hospital-acquired renal injury, and strategies for its treatment are currently lacking.
Kangxu He, Xiaoying Sun, Xinhui Pan, Xiaoda Yang, Qi Wang, Kai Liao   +5 more
doaj   +2 more sources

The Effective Treatment of Purpurin on Inflammation and Adjuvant-Induced Arthritis

Molecules, 2023
Rubia cordifolia L. (Rubiaceae), one of the traditional anti-rheumatic herbal medicines in China, has been used to treat rheumatoid arthritis (RA) since ancient times.
Weiya Zeng, Caihong Shen, Suifen Mo, Chen Ni, Ying Lin, Yuan Fang, Huiling Yang, Guihua Luo, Luhua Xiao, Ruoting Zhan, Ping Yan   +10 more
doaj   +3 more sources

Effects of geographical, soil and climatic factors on the two marker secondary metabolites contents in the roots of Rubia cordifolia L. [PDF]

Frontiers in Plant Science
The growth and quality of medicinal plants depend heavily on environmental variables. The quality of Rubia cordifolia, an important medicinal plant, is determined by the two main secondary metabolites of the root, purpurin and mollugin.
Yanlin Wang, Yanlin Wang, Yanlin Wang, Huanchu Liu, Huanchu Liu, Shuai Yu, Shuai Yu, Yue Zhang, Yue Zhang, Yue Zhang, Yanqing Huang, Yanqing Huang, Yanqing Huang, Xingyuan He, Xingyuan He, Xingyuan He, Xingyuan He, Wei Chen, Wei Chen, Wei Chen, Wei Chen   +20 more
doaj   +2 more sources

Anthraquinones Inhibit Insulin Amyloidosis in Crowded Environments [PDF]

Molecules
Natural anthraquinones possess a wide range of biological activities, including antibacterial, antiviral, antitumor, and antioxidant effects. However, studies on their ability to inhibit amyloid protein aggregation remain relatively limited.
Jiaxing Zhang, Wen Wang, Zubiyan Yibula, Xin Peng, Rongxin Su, Wei Qi   +5 more
doaj   +2 more sources

Dynamic analysis of growth characteristics, secondary metabolites accumulation, and an in-depth understanding of anthraquinones biosynthesis in Rubia cordifolia Linn. [PDF]

Frontiers in Plant Science
Rubia cordifolia is a well-known plant used in oriental medicine plant, and is also serves as the primary traditional source of plant red dyestuffs. With the current depletion of natural resources of R.
Conglong Lian, Conglong Lian, Conglong Lian, Xiuyu Liu, Xiuyu Liu, Kaihua Guo, Kaihua Guo, Hao Yang, Hao Yang, Jingfan Yang, Jingfan Yang, Jinxu Lan, Jinxu Lan, Suiqing Chen, Suiqing Chen, Suiqing Chen, Suiqing Chen   +16 more
doaj   +2 more sources

A purpurin-based metalloimmunostimulant amplifies ROS and modulates STING/TNF-α axis to potentiate melanoma immunotherapy [PDF]

Materials Today Bio
The low infiltration of pro-inflammatory immune cells and the sustained activation of multiple immunosuppressive signaling pathways in melanoma significantly limit the efficacy of clinical immunotherapy. Therefore, developing an effective immunostimulant
Xiaoxin Yang, Mi Huang, Tianyi Pang, Dong Zhong, Hong Liu, Xiang Chen, Jun Liu, Yu Wen   +7 more
doaj   +2 more sources

Purpurin suppresses Candida albicans biofilm formation and hyphal development.

PLoS ONE, 2012
A striking and clinically relevant virulence trait of the human fungal pathogen Candida albicans is its ability to grow and switch reversibly among different morphological forms. Inhibition of yeast-to-hypha transition in C.
Paul Wai-Kei Tsang, H M H N Bandara, Wing-Ping Fong   +2 more
doaj   +8 more sources

Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins [PDF]

Scientific Reports
Salmonella Typhimurium (S. Typhimurium, ST) is a food-borne pathogen that can be transmitted from animals to humans and causes symptoms such as diarrhea, fever, and vomiting.
Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu   +7 more
doaj   +2 more sources

Activity of Hydrophilic, Biocompatible, Fluorescent, Organic Nanoparticles Functionalized with Purpurin-18 in Photodynamic Therapy for Colorectal Cancer [PDF]

Nanomaterials
Photodynamic therapy (PDT) is a clinically approved, non-invasive therapy currently used for several solid tumors, triggering cell death through the generation of reactive oxygen species (ROS).
Rayan Chkair, Justine Couvez, Frédérique Brégier, Mona Diab-Assaf, Vincent Sol, Mireille Blanchard-Desce, Bertrand Liagre, Guillaume Chemin   +7 more
doaj   +2 more sources