Results 161 to 170 of about 96,322 (259)

ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to crizotinib

ObjectiveTo assess the influence of F1174S mutation on kinase activity and drug sensitivity of the echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) fusion (EML4-ALK) variants 1 and 3.MethodsWe constructed ...
Hallberg, Bengt,, Chuang, Tzu-Po,, Palmer, Ruth H.,, Palmer, Ruth H., Guan, Jikui,, Vikström, Anders,, Hallberg, Bengt, Vikström, Anders, Guan, Jikui, Chuang, Tzu-Po   +9 more
core   +1 more source

Molecular Characterization of Non‐Specific Esophagitis Reveals a Distinct Non‐Eosinophilic Phenotype With Fibrotic Traits

Allergy, EarlyView.
This study comprehensively characterizes non‐specific esophagitis and elucidates eosinophil‐independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with GERD and other chronic inflammatory disorders such as EoE or lymphocytic esophagitis.
Marc Pfefferle, Darko Stojkov, Dagmar Simon, Emilie Gueguen, Marcin Wawrzyniak, Margaret H. Collins, Mirna Chehade, Evan S. Dellon, Glenn T. Furuta, Ikuo Hirano, Nirmala Gonsalves, Fouad J. Moawad, Luc Biedermann, Alain M. Schoepfer, Alex Straumann, Hans‐Uwe Simon, Thomas Greuter   +16 more
wiley   +1 more source

Analysis of clinical features and outcomes in a Chinese cohort with <i>ALK</i> fusion across pan-cancer: a retrospective study. [PDF]

Front Oncol
Zhang M, Feng Y, Du X, Qu C, Meng M, Ye M, Liang M, Yang Z, Gong W, Ma X, Guo J, Li W, Jia S.   +12 more
europepmc   +1 more source

Profile of ceritinib in the treatment of ALK+ metastatic non-small-cell lung cancer

, 2015
Mark W Burns, Eric S Kim Wilmot Cancer Center, University of Rochester, Rochester, NY, USA Abstract: Lung cancer has become one of the leading causes of death in both men and women in the United States, with approximately 230,000 new cases and 160,000 ...
Burns MW, Kim ES
core  

Treatment Dose Increase Versus Co‐Medication in Allergic Rhinitis: Systematic Review With Dose–Response Network Meta‐Analysis

Allergy, EarlyView.
ABSTRACT Background To achieve adequate symptom control, patients with allergic rhinitis (AR) often need to increase their medication dose or add other treatments (co‐medication). We aimed to perform a systematic review to compare the efficacy and safety of AR medications for increased dose versus co‐medication.
Bernardo Sousa‐Pinto, Rafael José Vieira, Sara Gil‐Mata, Ana Margarida Pereira, Vítor Henrique Duarte, Antonio Bognanni, Manuel Marques‐Cruz, Paweł Jemioło, Mattia Giovannini, Danilo di Bona, Arnav Agarwal, Mark S. Dykewicz, Mohamed H. Shamji, Maria Jose Torres, Torsten Zuberbier, Ludger Klimek, Alexandro W. L. Chu, Holger J. Schünemann, Guido Schwarzer, João A. Fonseca, Jean Bousquet, on behalf of the ARIA 2024–2025 systematic reviews group, Ana Teixeira‐Ferreira, André Ferreira, António Cardoso‐Fernandes, Despo Ierodiakonou, Diana Portela, Ewa Borowiack, Ewelina Sadowska, Henrique Ferreira‐Cardoso, Hugo Viegas, Izabel Pera Calvi, João Castro‐Teles, José Laerte Boechat, Juliana Pereira‐Macedo, Maria Inês Torres, Marta Soares Pereira, Miguel Campos‐Lopes, Nuno Lourenço‐Silva, Pau Riera‐Serra, Paula Perestrelo, Raquel Albuquerque‐Costa, Renato Ferreira‐da‐Silva, Rita A. Silva Ribeiro, Tuuli Thomander   +44 more
wiley   +1 more source

ALK Expression Without ALK Rearrangement in EWSR1::ATF1-Fused Inflammatory and Nested Testicular Sex Cord Tumor. [PDF]

Diagnostics (Basel)
Kim MC, Kwon HJ, Kim SH.
europepmc   +1 more source

Overcoming Central β-Sheet #6 (Cβ6) ALK Mutation (L1256F), TP53 Mutations and Short Forms of EML4-ALK v3/b and v5a/b Splice Variants are the Unmet Need That a Re-Imagined 5th-Generation (5G) ALK TKI Must Deliver

Alexandria TM Lee,1 Sai-Hong Ignatius Ou1,2 1University of California Irvine School of Medicine, Department of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USACorrespondence: Sai-Hong Ignatius Ou, Division of ...
Lee ATM, Ou SI
core  

Lymphomas expressing ALK fusion protein(s) other than NPM-ALK

, 1999
The tumor cells in ALK-positive lymphoma ("ALKoma") usually express the product of the NPM-ALK chimeric gene, generated by the t(2;5) chromosomal translocation.
A. Santucci, S. Pileri, D. Y. Mason, J. Cordell, C. De Wolf Peeters, P. G. Pelicci, K. Pulford, A. Pucciarini, A. Carbone, G. Ott, B. Falini, M. Fizzotti, G. Delsol, E. Campo   +13 more
core  

Safety of Venom Immunotherapy in Pregnancy: A Multicentre Study

Allergy, EarlyView.
Venom immunotherapy (VIT) during pregnancy, when maintenance dose is well tolerated, can be continued. No increased risk of adverse effects to VIT or safety concerns for the pregnancy or the newborns were observed. No decreased efficacy of VIT, in case of re‐stings, was reported.
Matteo Martini, Giovanna Sfriso, Valerio Pravettoni, Marina Mauro, Donatella Preziosi, Francesca Vettorato, Giuseppe Lucchini, Mauro Pagani, Iuliana Badiu, Maria Pia Dolcher, Francesco Gaeta, Pietro Galati, Elisa Meucci, Elide Pastorello, Vincenzo Patella, Stefano Pucci, Chiara Roncallo, Eleonora Savi, Livio Simioni, Maria Beatrice Bilò, Patrizia Bonadonna   +20 more
wiley   +1 more source

Three decades of anaplastic lymphoma kinase: from physiological roles to cancer and immune evasion. [PDF]

Cancer Metastasis Rev
Amin HM, Aminnia S, Saber MM, Kannan MK, Hung J.   +4 more
europepmc   +1 more source