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Gan to kagaku ryoho. Cancer & chemotherapy, 2011
While lung cancer is the leading cause of cancer deaths worldwide, the molecular mechanism underlying its carcinogenesis is mainly unknown. We have discovered a small, fusion-type tyrosine kinase EML4-ALK that is generated through a tiny inversion within the short arm of human chromosome 2. Transgenic mice expressing EML4-ALK in lung developed hundreds
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While lung cancer is the leading cause of cancer deaths worldwide, the molecular mechanism underlying its carcinogenesis is mainly unknown. We have discovered a small, fusion-type tyrosine kinase EML4-ALK that is generated through a tiny inversion within the short arm of human chromosome 2. Transgenic mice expressing EML4-ALK in lung developed hundreds
openaire +1 more source
EML4-ALK Variant Affects ALK Resistance Mutations
Journal of Clinical Oncology, 2018Martin, Früh, Solange, Peters
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A selective ALK inhibitor in ALK-rearranged patients
The Lancet Oncology, 2013openaire +2 more sources