Results 111 to 120 of about 21,294 (218)

The genetic landscape of high-risk neuroblastoma [PDF]

, 2014
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%1. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we
Ally, Adrian, Asgharzadeh, Shahab, Attiyeh, Edward F., Auclair, Daniel, Auvil, Jaime M. Guidry, Badgett, Thomas, Birol, Inanc, Carter, Scott L., Chiu, Readman, Cibulskis, Kristian, Cole, Kristina A., Corbett, Richard D., Diamond, Maura, Diskin, Sharon J., Gabriel, Stacey B., Gastier-Foster, Julie M., Gerhard, Daniela S., Getz, Gad, Hanna, Megan, Hirst, Martin, Hogarty, Michael D., Jackman, Shaun D., Ji, Lingyun, Jones, Steven J. M., Kamoh, Baljit, Khan, Javed, Khodabakshi, Alireza Hadj, Kiezun, Adam, Kim, Jaegil, Krzywinski, Martin, Lander, Eric S., Lawrence, Michael S., Lichenstein, Lee, Lo, Allan, London, Wendy B., Maris, John M., Marra, Marco A., McKenna, Aaron, Meyerson, Matthew, Moore, Richard A., Morozova, Olena, Mosse, Yael P., Moyer, Yvonne, Mungall, Karen L., Pedamallu, Chandra Sekhar, Pugh, Trevor J., Qian, Jenny, Ramos, Alex H., Seeger, Robert C., Shefler, Erica, Sivachenko, Andrey, Smith, Malcolm A., Sougnez, Carrie, Sposto, Richard, Stewart, Chip, Tam, Angela, Thiessen, Nina, Wei, Jun S., Wood, Andrew C., Zhao, Yongjun   +59 more
core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Rare Lymphoid Malignancies of the Breast: A Report of Two Cases Illustrating Potential Diagnostic Pitfalls [PDF]

, 2012
Breast involvement by lymphoma is uncommon and poses challenges in diagnosis. Lymphomas may clinically, radiologically, and morphologically mimic both benign and neoplastic conditions.
Farkash, Evan Andrew, Ferry, Judith Ann, Harris, Nancy Lee, Hochberg, Ephraim Paul, Sohani, Aliyah, Takvorian, Ronald Wayne, Zuckerman, Dan S.   +6 more
core   +1 more source

Diagnosis for ALK Positive Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2015
The anaplastic lymphoma kinase (ALK) gene rearrangement is a driver gene of non-small cell lung cancer (NSCLC). Positive expression of ALK gene rearrangement has been considered a molecular subtype of NSCLC, that there are special pathological ...
Qin FENG, Xin YANG, Dongmei LIN
doaj   +1 more source

Restricted Expression of the Constant Region 1 of T‐Cell Receptor β by Flow Cytometry Facilitates Detection of T‐Cell Neoplasms With High Specificity but Moderate Predictive Value

European Journal of Haematology, Volume 116, Issue 3, Page 245-255, March 2026.
ABSTRACT Objectives To determine the diagnostic value of disclosing monotypic T‐cell populations by expression analysis of the constant region 1 of T‐cell receptor β (TRBC1) by flow cytometry, for the detection of T‐cell neoplasms, in a routine hematopathology practice setting.
Nilofar Rajabian, Olof Axler, Erik Wistén, Anna Porwit, Mats Ehinger   +4 more
wiley   +1 more source

Detection of Anaplastic Lymphoma Kinase Gene Re-Arrangement in Non-Small Cell Lung Carcinoma in the Indian Population: Comparison of Techniques and Immunohistochemistry Clones

Türk Patoloji Dergisi, 2019
Objective: Predictive and prognostic markers have revolutionized personalized therapy in non-small cell lung carcinoma (NSCLC). Crizotinib is now approved for locally advanced or metastatic NSCLC that is anaplastic lymphoma kinase (ALK) positive by ...
Saumya SHUKLA, Rahul Kumar PANDEY, Surya KANT, Rajiv GARG, Nidhi ANAND, Ram Awadh Singh KUSHWAHA, Kiran Preet MALHOTRA, Anand SRIVASTAVA, Madan Lal Brahma BHATT, Nuzhat HUSAIN   +9 more
doaj   +1 more source

Incidence and Outcome of Infants With Cancer in Canada: A Report From Cancer in Young People in Canada Database

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Purpose Infants with cancer are rare and face unique challenges. Our study aims to describe the incidence of infantile cancers in Canada and to compare treatment‐related mortality (TRM) and their outcomes with those of older children. Methods We conducted a retrospective cohort study using the Cancer in Young People in Canada database ...
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Sylvia Cheng, Lesleigh Abbott, Tony Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Donna L. Johnston, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +22 more
wiley   +1 more source

The prognostic implications of EGFR mutation and ALK rearrangement for the long‐term outcomes of patients with resected lung adenocarcinomas

Thoracic Cancer, 2019
Background To investigate the prognostic impact of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement for the overall survival (OS) of patients with surgically treated lung adenocarcinomas. Methods A total
Hyungjin Kim, Hyun‐Ju Lee, Hyunsook Hong, Young Jae Kim, Kwang Gi Kim, Yoon Kyung Jeon, Young Tae Kim   +6 more
doaj   +1 more source

Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression

BMC Cancer, 2018
Objective Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI).
Rui-Lian Chen, Jun Zhao, Xu-Chao Zhang, Na-Na Lou, Hua-Jun Chen, Xue Yang, Jian Su, Zhi Xie, Qing Zhou, Hai-Yan Tu, Wen-Zhao Zhong, Hong-Hong Yan, Wei-Bang Guo, Yi-Long Wu, Jin-Ji Yang   +14 more
doaj   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source