Results 1 to 10 of about 159,072 (309)

scTCR-seq and HTS reveal a special novel TRBD2-TRBJ1 rearrangement in mammalian TRB CDR3 repertoire

BMC Genomics
Mammalian T cell receptor (TCR) beta-chain (TRB) V-D-J rearrangement mainly follows the “12/23 rule”, and the “D-J rearrangement preceding the V-(D-J) rearrangement”.
Yingjie Wu, Fengli Wu, Jun Li, Hao Zhou, Long Ma, Xinsheng Yao   +5 more
doaj   +1 more source

Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

Scientific Reports, 2022
Vertebrate mitochondrial genomes have been extensively studied for genetic and evolutionary purposes, these are normally believed to be extremely conserved, however, different cases of gene rearrangements have been reported.
Paula Montaña-Lozano, Manuela Moreno-Carmona, Mauricio Ochoa-Capera, Natalia S. Medina, Jeffrey L. Boore, Carlos F. Prada   +5 more
doaj   +1 more source

Dynamics of Sea Urchin Gastrulation Revealed by Tracking Cells of Diverse Lineage and Regulatory State [PDF]

, 2011
During gastrulation in the sea urchin embryo the archenteron, or primitive gut, is formed by an initial process of invagination at the vegetal pole of the embryo, followed by extension across the blastocoel toward the future mouth.
Barnet, Matthew Edward
core   +1 more source

ERG rearrangement is associated with prostate cancer-related death in Chinese prostate cancer patients.

PLoS ONE, 2014
Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management.
Mei Qi, Xiaoqing Yang, Fan Zhang, Tao Lin, Xiubin Sun, Yanjiang Li, Huiqing Yuan, Yubo Ren, Juan Zhang, Xiaomin Qin, Bo Han   +10 more
doaj   +1 more source

T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]

PLoS ONE, 2014
Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma, Rosa Berga-Bolaños, Jyoti Misra Sen   +2 more
doaj   +1 more source

Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes [PDF]

, 2002
Comparisons between the genomes of the closely related nematodes Caenorhabditis elegans and Caenorhabditis briggsae reveal high rates of rearrangement, with a bias towards within-chromosome events.
CH Corton, SJM Jones, BG Barrell, Hall, N, Blaxter, Mark, Guiliano, D B, LN Clark, Barrell, B G, Corton, C H, Blaxter, M L, N Hall, DB Guiliano, Clark, L N, Jones, S J M, ML Blaxter   +14 more
core   +1 more source

The reverse TRBV30 gene of mammals: a defect or superiority in evolution?

BMC Genomics
At the 3’ end of the C2 gene in the mammalian TRB locus, a distinct reverse TRBV30 gene (named TRBV31 in mice) has been conserved throughout evolution.
Fengli Wu, Yingjie Wu, Yuanning Yao, Yuanyuan Xu, Qi Peng, Long Ma, Jun Li, Xinsheng Yao   +7 more
doaj   +1 more source

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior

Indian Journal of Pathology and Microbiology, 2015
Inflammatory myofibroblastic tumor (IMT), an intermediate-grade neoplasm of myofibroblastic/fibroblastic differentiation, occurs commonly in children and young adults.
Bhawna Sethi, Trupti Pai, Abhishek Allam, Sridhar Epari   +3 more
doaj   +1 more source

Genomic distance under gene substitutions

, 2011
Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. Genomic distance under gene substitutions. BMC Bioinformatics. 2011;12(Suppl 9: Proc. of RECOMB-CG 2011): S8.Background: The distance between two genomes is often computed by comparing only the common
Stoye Jens, Braga Marília D V, Jens Stoye, Machado, Raphael, Marília D V Braga, Stoye, Jens ; https://orcid.org/, Raphael Machado, Leonardo C Ribeiro, Machado Raphael, Dias Vieira Braga, Marília, Ribeiro, Leonardo C., Ribeiro Leonardo C   +11 more
core   +1 more source

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells

Frontiers in Immunology, 2018
To date there has not been a study directly comparing relative Igκ rearrangement frequencies obtained from genomic DNA (gDNA) and cDNA and since each approach has potential biases, this is an important issue to clarify.
Eden Kleiman, Salvatore Loguercio, Ann J. Feeney   +2 more
doaj   +1 more source