Results 41 to 50 of about 159,072 (309)

Case Report: Patient With Lung Adenocarcinoma With ALK-HLA-DRB1 Rearrangement Shows Impressive Progression-Free Survival After Sequential Crizotinib and Ceritinib Treatment

Frontiers in Oncology, 2022
The anaplastic lymphoma kinase (ALK) gene rearrangement is a driving mutation that underlies about 5-6% of non-small cell lung cancer (NSCLC) cases. Lung cancers that are ALK gene rearrangement-positive can be effectively treated with ALK inhibitors ...
Peng Gao, Kangning Tang, Yuqiu Hao, Wei Li, Xuejiao Lv, Dapeng Li, Yuxi Jia   +6 more
doaj   +1 more source

The clinical characteristics of autoimmune haemolytic anaemia/Evans syndrome patients with clonal immunoglobulin/T cell receptor gene rearrangement

Autoimmunity, 2020
Objective To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. Methods Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study.
Hongli Zhu, Manjun Zhao, Zeng Cao, Jin Yang, Yi Li, Limin Xing   +5 more
doaj   +1 more source

Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP

Haematologica, 2010
Background BCL6 gene rearrangement is the most frequent chromosomal abnormality in diffuse large B-cell lymphoma, a malignancy characterized by genetic heterogeneity and wide variability in clinical outcome.
Jesse Shustik, Guangming Han, Pedro Farinha, Nathalie A. Johnson, Susana Ben Neriah, Joseph M. Connors, Laurie H. Sehn, Douglas E. Horsman, Randy D. Gascoyne, Christian Steidl   +9 more
doaj   +1 more source

Novel case of coexisting TCF3 and IGH gene rearrangement in pediatric B-cell acute lymphoblastic leukemia: Favorable response to steroids and standard chemotherapy

Indian Journal of Pathology and Microbiology
B-ALL, a genetically heterogeneous disease, is predominantly characterized by translocations leading to the formation of chimeric fusion proteins, which are known leukemia drivers.
Anurag Gupta, Nishant Verma, Ashish Misra   +2 more
doaj   +1 more source

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann, Moore, Jonathan D., Heslop-Harrison, J. (John), King , Graham J., Ryder, C. D., Heslop-Harrison, J. S., Joets, J., Bailey, John P., Moore, J., Ryder, Carol D., Bailey, J. P., Alix, K., Barker, G. C., King, G. J., Barker, Guy C., Alix, Karine   +15 more
core   +1 more source

A Case of Rearrangement of Genes in Drosophila [PDF]

Proceedings of the National Academy of Sciences, 1921
Seven mutant genes of Drosophila simulans have been shown to be allelomorphic to previously known mutant genes of D. melanogaster. Five of these lie in the X-chromosome, and a study of their linkage relations was shown to indicate that the sequence of the five loci concerned is the same in both species, and that the percentages of crossing over in ...
openaire   +3 more sources

Analysis of Clonal Rearrangement Characteristics and Clinical Application Value of IGH in B-cell Non-Hodgkin’s Lymphoma by Next-generation Sequencing

Zhongliu Fangzhi Yanjiu
Objective To investigate the clonal rearrangement characteristics and clinical application value of IGH gene in B-cell non-Hodgkin’s lymphoma (B-NHL). Methods Demographic and clinical data as well as IGH sequencing results of 55 patients with B-NHL who ...
MA Qiang, ZOU Dongmei, GUO Yixian, ZHAO Hong, CHANG Xiaoli, HU Ronghua, SUN Wanling   +6 more
doaj   +1 more source

Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis

Diagnostic Pathology, 2023
Background Epithelioid and spindle rhabdomyosarcoma (ES-RMS) with TFCP2 rearrangement is a recently discovered rare variant of rhabdomyosarcoma composed of epithelioid and spindle cells, because it shows extraordinarily adverse prognosis and is easily ...
Yuan Li, Dan Li, Jingyu Wang, Jinlong Tang   +3 more
doaj   +1 more source

On the similarity of sets of permutations and its applications to genome comparison

, 2003
Bergeron A, Stoye J. On the similarity of sets of permutations and its applications to genome comparison. In: Proc. of COCOON 2003. LNCS. Vol 2697.
Jens Stoye, Bergeron, Anne, Stoye, Jens ; https://orcid.org/, Anne Bergeron   +3 more
core   +1 more source

Programmed Gene Rearrangements Altering Gene Expression

Science, 1987
Programmed gene rearrangements are used in nature to alter gene copy number (gene amplification and deletion), to create diversity by reassorting gene segments (as in the formation of mammalian immunoglobulin genes), or to control the expression of a set of genes that code for the same function (such as surface antigens).
Borst, P, Greaves, D
openaire   +3 more sources