Results 1 to 10 of about 618,200 (315)

Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia

Frontiers in Immunology, 2023
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate.
Zoltán Szittner, Zoltán Szittner, Arthur E. H. Bentlage, Arthur E. H. Bentlage, A. Robin Temming, A. Robin Temming, David E. Schmidt, David E. Schmidt, Remco Visser, Remco Visser, Suzanne Lissenberg-Thunnissen, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Myrthe E. Sonneveld, Erik L. de Graaf, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, Masja de Haas, Masja de Haas, C. Ellen van der Schoot, C. Ellen van der Schoot, Gestur Vidarsson, Gestur Vidarsson   +26 more
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A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors

Scientific Reports, 2022
Anti-tumor therapies that seek to exploit and redirect the cytotoxic killing and effector potential of autologous or syngeneic T cells have shown extraordinary promise and efficacy in certain clinical settings.
Julie K. Fierle, Johan Abram-Saliba, Vasileios Atsaves, Matteo Brioschi, Mariastella de Tiani, Patrick Reichenbach, Melita Irving, George Coukos, Steven M. Dunn   +8 more
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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
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Early immune system alterations in patients with septic shock

Frontiers in Immunology, 2023
This study aims to investigate the early changes in the immune systems of patients with septic shock. A total of 243 patients with septic shock were included in this study.
Huiming Tang, Shuang Qin, Zhanfei Li, Wei Gao, Manli Tang, Xijie Dong   +5 more
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Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs

Frontiers in Immunology, 2022
Ectopic tertiary lymphoid organs (TLOs) have been identified in many organs, such as the lungs, nasal cavities, and kidneys of both mice and humans. Although lymphocyte aggregates have been observed in the mammary glands of ruminants, the details remain ...
Yusaku Tsugami, Sayaka Nakayama, Naoki Suzuki, Takahiro Nii, Naoki Isobe   +4 more
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Effectiveness of Echinacea purpurea extract on immune deficiency induced by azathioprine in male albino rats

Bioscience Journal, 2021
This study was performed to evaluate the effectiveness of Echinacea purpurea (E.P.) on azathioprine (AZA)-induced immune deficiency in albino rats. Thirty six male albino rats were divided into six equal groups.
Emad Mohamed El-Sherbiny, Hala Fawzy Osman, Mervat Sayed Taha   +2 more
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B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma

Frontiers in Immunology, 2021
In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal surfaces of the upper and lower ...
Line Ohm-Laursen, Line Ohm-Laursen, Hailong Meng, Kenneth B. Hoehn, Nima Nouri, Nima Nouri, Yue Jiang, Chris Clouser, Timothy G. Johnstone, Ron Hause, Balraj S. Sandhar, Balraj S. Sandhar, Nadine E. G. Upton, Nadine E. G. Upton, Elfy B. Chevretton, Raj Lakhani, Chris J. Corrigan, Chris J. Corrigan, Steven H. Kleinstein, Steven H. Kleinstein, Steven H. Kleinstein, Hannah J. Gould, Hannah J. Gould   +22 more
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Inclusion of Oat and Yeast Culture in Sow Gestational and Lactational Diets Alters Immune and Antimicrobial Associated Proteins in Milk

Animals, 2021
Maternal diet supplementation with pro- and prebiotics is associated with decreased incidence of diarrhea and greater piglet performance. This study investigated the impact adding whole ground oat as a prebiotic, alone or in combination with a probiotic,
Barry Donovan, Aridany Suarez-Trujillo, Theresa Casey, Uma K. Aryal, Dawn Conklin, Leonard L. Williams, Radiah C. Minor   +6 more
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A Novel IGLC2 Gene Linked With Prognosis of Triple-Negative Breast Cancer

Frontiers in Oncology, 2022
BackgroundImmunoglobulin-related genes are associated with the favorable prognosis of triple-negative breast cancer (TNBC) patients. We aimed to analyze the function and prognostic value of immunoglobulin lambda constant 2 (IGLC2) in TNBC patients ...
Yu-Tien Chang, Wen-Chiuan Tsai, Wei-Zhi Lin, Chia-Chao Wu, Jyh-Cherng Yu, Vincent S. Tseng, Guo-Shiou Liao, Je-Ming Hu, Je-Ming Hu, Je-Ming Hu, Huan-Ming Hsu, Huan-Ming Hsu, Yu-Jia Chang, Yu-Jia Chang, Yu-Jia Chang, Meng-Chiung Lin, Meng-Chiung Lin, Chi-Ming Chu, Chi-Ming Chu, Chi-Ming Chu, Chi-Ming Chu, Chien-Yi Yang   +21 more
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Reemergence of Human Monkeypox and Declining Population Immunity in the Context of Urbanization, Nigeria, 2017–2020

Emerging Infectious Diseases, 2021
A monkeypox outbreak in Nigeria during 2017–2020 provides an illustrative case study for emerging zoonoses. We built a statistical model to simulate declining immunity from monkeypox at 2 levels: At the individual level, we used a constant rate of ...
Phi-Yen Nguyen, Whenayon Simeon Ajisegiri, Valentina Costantino, Abrar A. Chughtai, C. Raina MacIntyre   +4 more
doaj   +1 more source