Results 31 to 40 of about 848,800 (312)

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching [PDF]

, 1998
Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement.
Alt, Frederick W., Davidson, Laurie, Ferrini, Roger, Gu, Yansong, Lansford, Rusty, Manis, John P., Rajewsky, Klaus, Sonoda, Eiichiro   +7 more
core   +2 more sources

Single Domain Antibody Fragments as Drug Surrogates Targeting Protein–Protein Interactions inside Cells

Antibodies, 2013
Many human diseases are caused by mutant or abnormal protein functions that are largely confined to the inside of cells, rather than being displayed on the abnormal cell surface. Furthermore, many of the functional consequences of aberrant proteins, such
Terence H. Rabbitts, Jing Zhang, Tomoyuki Tanaka, Jia Zeng   +3 more
doaj   +1 more source

The antibody loci of the domestic goat (Capra hircus) [PDF]

, 2018
The domestic goat (Capra hircus) is an important ruminant species both as a source of antibody-based reagents for research and biomedical applications and as an economically important animal for agriculture, particularly for developing nations that ...
Bickhart, Derek M., Hammond, John A., Philp, Rebecca L., Schwartz, John C., Smith, Timothy P.L.   +4 more
core   +1 more source

Vogt-Koyanagi-Harada Syndrome in Two Patients with Immunoglobulin A Nephropathy [PDF]

, 2007
We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-
Masuda, Ikuya, Matsuo, Toshihiko, Nose, Soichiro, Ota, Kosuke, Sunami, Reiko, Yamadori, Ichiro   +5 more
core   +1 more source

Dose, exposure, and treatment regimen of intravenous immunoglobulin G in multifocal motor neuropathy

Frontiers in Neurology
IntroductionIntravenous immunoglobulin (IVIG) is the only approved treatment for multifocal motor neuropathy (MMN), a rare, chronic, immune-mediated demyelinating neuropathy. There is a significant gap in understanding of the role of serum immunoglobulin
Zhaoyang Li, Stefan Roepcke, Ryan Franke, Leman Yel   +3 more
doaj   +1 more source

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]

, 2016
Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht, Changjun Yin, Christian Weber, Coleen A. McNamara, Desheng Hu, Gianluca Grassia, Kulkarni U, Li Peng, Michael Beer, Pasquale Maffia, Prasad Srikakulapu, Rudolf A. Manz, Sai Vineela Bontha, Sarajo K. Mohanta   +13 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Celebrating More Than a Century of Research on Antibodies: Affirmation Through Negation via Complex Formation

Pathogens and Immunity, 2017
In this brief commentary, I highlight the remarkable properties of antibodies (also known as immunoglobulins) revealed by more than 100 years of biomedical research.
Neil S. Greenspan
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Oregano Essential Oil as a Natural Plant Additive Affects Growth Performance and Serum Antibody Levels by Regulating the Rumen Microbiota of Calves

Animals
This experiment aimed to investigate whether supplementation of calves with different doses of oregano essential oil (OEO) could promote the development of the gastrointestinal tract and enhance the immune ability of calves by regulating the rumen ...
Zhihao Luo, Ting Liu, Dongzhu Cairang, Shuru Cheng, Jiang Hu, Bingang Shi, Hui Zhu, Huan Chen, Tao Zhang, Xuejiao Yi   +9 more
doaj   +1 more source