Results 41 to 50 of about 618,200 (315)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

TNF-α x FcαRI bi-specific antibody potentiates neutrophil-mediated anti-tumor effects

Scientific Reports
Immunotherapy has emerged as a promising strategy against cancer, but many patients fail to achieve durable responses. Inefficiency of immunotherapy is often caused by the immunosuppressive tumor microenvironment.
D. Y. Gout, C. A. N. Sewnath, G. Duru, R. van der Mast, C. W. Tuk, A. E. H. Bentlage, M. Gruijs, G. Vidarsson, N. Heemskerk, M. van Egmond   +9 more
doaj   +1 more source

Transfer of passive immunity in dairy calves: the effectiveness of providing a supplementary colostrum meal in addition to nursing from the dam

Animal, 2019
Failed transfer of passive immunity (FTPI) in dairy calves – which is often due to the low amount of colostrum provided within a few hours after birth – remains a crucial issue.
I. Lora, F. Gottardo, L. Bonfanti, A.L. Stefani, E. Soranzo, B. Dall’Ava, K. Capello, M. Martini, A. Barberio   +8 more
doaj   +1 more source

Anaphylactoid Reactions Following Red Blood Cell Transfusion in a Patient with Previously Undiagnosed Immunoglobulin A Deficiency: Case Report [PDF]

, 2023
A 73-year-old, 104 kg female patient was hospitalised for debulking and low anterior colon resection operations. Anaphylactoid symptoms devel-oped when administering erythrocyte suspension and fresh frozen plasma.
Tümay Uludağ Yanaral, Hande Güngör, Karaaslan, Pelin, Güngör, Hande, Uzunoğlu, Emine, Emine Uzunoğlu, Pelin Karaaslan, Uludağ Yanaral, Tümay   +7 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria

Nature Communications
Protective immunity to malaria depends on acquisition of parasite-specific antibodies, with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) being one of the most important target antigens.
Mary Lopez-Perez, Zakaria Seidu, Mads Delbo Larsen, Wenjun Wang, Jan Nouta, Manfred Wuhrer, Gestur Vidarsson, Michael F. Ofori, Lars Hviid   +8 more
doaj   +1 more source

Genetic associations of colostrum yield with antibody concentrations and gross composition for selective breeding in Italian Holsteins

Journal of Dairy Science
: The quality of bovine colostrum (BC), primarily determined by the concentration of IgG, is essential for the transfer of passive immunity and the development of the gastrointestinal tract in neonates.
Arianna Goi, Angela Costa, Mauro Penasa, Martino Cassandro, Maurizio Marusi, Raffaella Finocchiaro, Massimo De Marchi   +6 more
doaj   +1 more source

Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis

Frontiers in Immunology, 2021
The protein tyrosine phosphatase receptor type-C (PTPRC) gene encodes the common leukocyte antigen (CD45) receptor. CD45 affects cell adhesion, migration, cytokine signalling, cell development, and activation state.
Nicholas N. Jonsson, David K. Cox, Emily K. Piper, Emily F. Mantilla Valdivieso, Constantin Constantinoiu, Louise A. Jackson, Michael J. Stear, Elizabeth M. Ross, Ala E. Tabor   +8 more
doaj   +1 more source

Fish Immunoglobulins [PDF]

Biology, 2016
The B cell receptor and secreted antibody are at the nexus of humoral adaptive immunity. In this review, we summarize what is known of the immunoglobulin genes of jawed cartilaginous and bony fishes. We focus on what has been learned from genomic or cDNA sequence data, but where appropriate draw upon protein, immunization, affinity and structural ...
Sara Mashoof, Michael F. Criscitiello
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source