Results 11 to 20 of about 666,636 (307)

Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia

Frontiers in Immunology, 2023
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate.
Zoltán Szittner, Zoltán Szittner, Arthur E. H. Bentlage, Arthur E. H. Bentlage, A. Robin Temming, A. Robin Temming, David E. Schmidt, David E. Schmidt, Remco Visser, Remco Visser, Suzanne Lissenberg-Thunnissen, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Myrthe E. Sonneveld, Erik L. de Graaf, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, Masja de Haas, Masja de Haas, C. Ellen van der Schoot, C. Ellen van der Schoot, Gestur Vidarsson, Gestur Vidarsson   +26 more
doaj   +1 more source

A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors

Scientific Reports, 2022
Anti-tumor therapies that seek to exploit and redirect the cytotoxic killing and effector potential of autologous or syngeneic T cells have shown extraordinary promise and efficacy in certain clinical settings.
Julie K. Fierle, Johan Abram-Saliba, Vasileios Atsaves, Matteo Brioschi, Mariastella de Tiani, Patrick Reichenbach, Melita Irving, George Coukos, Steven M. Dunn   +8 more
doaj   +1 more source

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +1 more source

Early immune system alterations in patients with septic shock

Frontiers in Immunology, 2023
This study aims to investigate the early changes in the immune systems of patients with septic shock. A total of 243 patients with septic shock were included in this study.
Huiming Tang, Shuang Qin, Zhanfei Li, Wei Gao, Manli Tang, Xijie Dong   +5 more
doaj   +1 more source

Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs

Frontiers in Immunology, 2022
Ectopic tertiary lymphoid organs (TLOs) have been identified in many organs, such as the lungs, nasal cavities, and kidneys of both mice and humans. Although lymphocyte aggregates have been observed in the mammary glands of ruminants, the details remain ...
Yusaku Tsugami, Sayaka Nakayama, Naoki Suzuki, Takahiro Nii, Naoki Isobe   +4 more
doaj   +1 more source

Immunoglobulins and immunoglobulin subclasses in the elderly [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003
Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses.
R J, Lock, D J, Unsworth
openaire   +2 more sources

Gene conversion in human rearranged immunoglobulin genes [PDF]

, 2006
Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V_H segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
Darlow, J.M., John M. Darlow, David I. Stott, Stott, D.I.   +3 more
core   +1 more source

Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement [PDF]

, 2014
Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients
Matthew Buckland (589995), Lorena Lorenzo (589997), Matthew Buckland, Dempster, J, Duraisingham Sai S., Longhurst Hilary J., Matthew Buckl, Sai S. Duraisingham, Sofia Grigoriadou (589998), Sai S Duraisingham, Hilary J Longhurst, John Dempster, Dempster John, Grigoriadou Sofia, Duraisingham, SS, Lorenzo, L, Buckland Matthew, Grigoriadou, S, Sofia Grigoriadou, Lorenzo Lorena, Sai S. Duraisingham (589994), Buckland, M, Longhurst, HJ, Lorena Lorenzo, John Dempster (589996), Buckland, MS, Hilary J. Longhurst (589999), Hilary J. Longhurst   +27 more
core   +2 more sources

Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]

, 1988
The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas, Straubinger, Bernhard, Lötscher, Erika, Zachau, Hans G., Zimmer, Franz-Josef, Jaenichen, Rita, Grzeschik, Karl-Heinz   +6 more
core   +1 more source

Identification of the ancestral killer immunoglobulin-like receptor gene in primates [PDF]

, 2006
Background: Killer Immunoglobulin-like Receptors (KIR) are essential immuno- surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte antigens.
Penny Coggill, Hanne Andersen, Sambrook Jennifer G, Piatak Mike, Carrington Mary, Jennifer G Sambrook, Coggill, P, Stephan Beck, Carrington, M, Piatak, M, Vernikos George S, Mike Piatak, Vernikos, GS, Bashirova Arman, Beck Stephan, Coggill Penny, Bashirova, A, Lifson, JD, Andersen, H, George S Vernikos, Lifson Jeff D, Beck, S, Jeff D Lifson, Andersen Hanne, Arman Bashirova, Mary Carrington, Sambrook, JG   +26 more
core   +1 more source