Immunoglobulins and immunoglobulin subclasses in the elderly [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003 Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses.
R J, Lock, D J, Unsworth
openaire +2 more sources
Gene conversion in human rearranged immunoglobulin genes [PDF]
, 2006 Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V<sub>H</sub> segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
Darlow, J.M. +3 more
core +1 more source
Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]
, 1988 The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas +6 more
core +1 more source
Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement [PDF]
, 2014 Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients
Matthew Buckland (589995) +27 more
core +1 more source
The immunoglobulin κ gene families of human and mouse: a cottage industry approach [PDF]
, 2000 Some aspects of the work of our group on the human and mouse immunoglobulin κ genes are reviewed. The human κ locus contains a large duplication: a 600 kb C κ-proximal copy with 40 V κ genes is found in the close vicinity of a 440 kb C κ-distal copy with
Zachau, Hans G.
core +1 more source
Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]
, 2004 86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M. +5 more
core +1 more source
Intravenous immunoglobulin treatment in children with PANS/PANDAS conditions [PDF]
, 2021 Key messages: PANS (Pediatric Acute onset Neuropsychiatric Syndrome)/PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections) is described as an abrupt, dramatic onset of obsessive-compulsive disorder (OCD) or ...
Grøvan, Anette Olsson +1 more
core
STUDY ON CHEMICAL AND BIOLOGICAL PARAMETERS OF COLOSTRUM IN ROMANIAN BLACK AND WHITE COWS
Scientific Papers Animal Science and Biotechnologies, 2023 The aim of the paper was to evaluate the colostrum quality and changes in composition during the first seven days postpartum. Researches were carried out on five Romanian Black and White multiparous cows.
L. T. CZISZTER +6 more
doaj
Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish
eLife, 2022 Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however ...
William John Bradshaw +4 more
doaj +1 more source
Frontiers in Immunology, 2020 We report on an observational, multicenter study of 345 adult CVID patients, designed to assess the diagnostic value and the clinical association of serum free light chain (sFLC) pattern in Common Variable Immunodeficiency disorders (CVID).
Riccardo Scarpa +22 more
doaj +1 more source