Results 31 to 40 of about 264,764 (308)

Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP

Haematologica, 2010
Background BCL6 gene rearrangement is the most frequent chromosomal abnormality in diffuse large B-cell lymphoma, a malignancy characterized by genetic heterogeneity and wide variability in clinical outcome.
Jesse Shustik, Guangming Han, Pedro Farinha, Nathalie A. Johnson, Susana Ben Neriah, Joseph M. Connors, Laurie H. Sehn, Douglas E. Horsman, Randy D. Gascoyne, Christian Steidl   +9 more
doaj   +1 more source

Novel case of coexisting TCF3 and IGH gene rearrangement in pediatric B-cell acute lymphoblastic leukemia: Favorable response to steroids and standard chemotherapy

Indian Journal of Pathology and Microbiology
B-ALL, a genetically heterogeneous disease, is predominantly characterized by translocations leading to the formation of chimeric fusion proteins, which are known leukemia drivers.
Anurag Gupta, Nishant Verma, Ashish Misra   +2 more
doaj   +1 more source

Is now the time for molecular driven therapy for diffuse large B-cell lymphoma? [PDF]

, 2017
INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder.
Ansuinelli, Michela, DE ANGELIS, Federico, DI ROCCO, Alice, Foa, Roberto, Martelli, Maurizio   +4 more
core   +1 more source

Epithelioid and spindle rhabdomyosarcoma with TFCP2 rearrangement in abdominal wall: a distinctive entity with poor prognosis

Diagnostic Pathology, 2023
Background Epithelioid and spindle rhabdomyosarcoma (ES-RMS) with TFCP2 rearrangement is a recently discovered rare variant of rhabdomyosarcoma composed of epithelioid and spindle cells, because it shows extraordinarily adverse prognosis and is easily ...
Yuan Li, Dan Li, Jingyu Wang, Jinlong Tang   +3 more
doaj   +1 more source

Hidden breakpoints in genome alignments

, 2012
During the course of evolution, an organism's genome can undergo changes that affect the large-scale structure of the genome. These changes include gene gain, loss, duplication, chromosome fusion, fission, and rearrangement.
A. Rambaut, A.C.E. Darling, A.E. Darling, A.L. Delcher, C.D. Greenman, D. Medini, E. Tannier, G. Fudenberg, M. Blanchette, M. Nowacki, M.A. Umbarger, S. De, S. Schwartz, S.V. Angiuoli, V. Kolmogorov   +14 more
core   +1 more source

Analysis of Clonal Rearrangement Characteristics and Clinical Application Value of IGH in B-cell Non-Hodgkin’s Lymphoma by Next-generation Sequencing

Zhongliu Fangzhi Yanjiu
Objective To investigate the clonal rearrangement characteristics and clinical application value of IGH gene in B-cell non-Hodgkin’s lymphoma (B-NHL). Methods Demographic and clinical data as well as IGH sequencing results of 55 patients with B-NHL who ...
MA Qiang, ZOU Dongmei, GUO Yixian, ZHAO Hong, CHANG Xiaoli, HU Ronghua, SUN Wanling   +6 more
doaj   +1 more source

Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

Scientific Reports, 2022
Vertebrate mitochondrial genomes have been extensively studied for genetic and evolutionary purposes, these are normally believed to be extremely conserved, however, different cases of gene rearrangements have been reported.
Paula Montaña-Lozano, Manuela Moreno-Carmona, Mauricio Ochoa-Capera, Natalia S. Medina, Jeffrey L. Boore, Carlos F. Prada   +5 more
doaj   +1 more source

Detection of t(7;12)(q36;p13) in paediatric leukaemia using dual colour fluorescence in situ hybridisation [PDF]

, 2015
The identification of chromosomal rearrangements is of utmost importance for the diagnosis and classification of specific leukaemia subtypes and therefore has an impact on therapy choices in individual cases.
Federico, C, Owoka, T, Saccone, S, Tosi, S, Vetter, M   +4 more
core   +2 more sources

scTCR-seq and HTS reveal a special novel TRBD2-TRBJ1 rearrangement in mammalian TRB CDR3 repertoire

BMC Genomics
Mammalian T cell receptor (TCR) beta-chain (TRB) V-D-J rearrangement mainly follows the “12/23 rule”, and the “D-J rearrangement preceding the V-(D-J) rearrangement”.
Yingjie Wu, Fengli Wu, Jun Li, Hao Zhou, Long Ma, Xinsheng Yao   +5 more
doaj   +1 more source

Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma [PDF]

, 2009
Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma.
Akagi, Tadaatsu, Kobayashi, Keita, Mannami, Tomohiko, Miyake, Takayoshi, Munemasa, Mitsuru, Sakugawa, Sumie Takase, Shinagawa, Katsuji, Tanimoto, Mitsune, Yoshino, Tadashi   +8 more
core   +1 more source