Results 1 to 10 of about 4,979,257 (318)

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

open access: yesJournal of Neuroinflammation, 2023
Background Microglia, the brain’s principal immune cells, have been implicated in the pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more females than males.
Sarah R. Ocañas   +14 more
doaj   +1 more source

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

open access: yesJournal of Immunology Research, 2022
Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully ...
Lei Zhu   +7 more
doaj   +1 more source

Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis

open access: yesJournal of Immunology Research, 2022
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of ...
Yue Sun   +8 more
doaj   +1 more source

Puncture, MRI and NMR relaxometry data for multiscale analysis of the degradation of apple structure due to thermal treatment

open access: yesData in Brief, 2021
The data presented here are related to the research paper entitled “Multiscale NMR analysis of the degradation of apple structure due to thermal treatment” whose aim was to investigate the critical temperature at which the cell membranes of a Golden ...
Alexandre Leca   +4 more
doaj   +1 more source

Characterization of integrated prophages within diverse species of clinical nontuberculous mycobacteria

open access: yesVirology Journal, 2020
Background Nontuberculous mycobacterial (NTM) infections are increasing in prevalence, with current estimates suggesting that over 100,000 people in the United States are affected each year.
Cody Glickman   +5 more
doaj   +1 more source

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

open access: yesNature Communications, 2020
Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tuft ...
Katherine C. Goldfarbmuren   +11 more
doaj   +1 more source

Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools

open access: yesScientific Reports, 2017
Genetic access to small, reproducible sets of neurons is key to an understanding of the functional wiring of the brain. Here we report the generation of a new Gal4- and Cre-driver resource for zebrafish neurobiology.
Dominique Förster   +14 more
doaj   +1 more source

Simulation study and comparative evaluation of viral contiguous sequence identification tools

open access: yesBMC Bioinformatics, 2021
Background Viruses, including bacteriophages, are important components of environmental and human associated microbial communities. Viruses can act as extracellular reservoirs of bacterial genes, can mediate microbiome dynamics, and can influence the ...
Cody Glickman   +2 more
doaj   +1 more source

Estudio genético de una muestra poblacional del departamento de Bolivar con 10 marcadores ligados al cromosoma X

open access: yesIatreia, 2010
Los marcadores del cromosoma X se han utilizado en identificación humana y en pruebas de paternidad desde la década de los setenta, entre los más conocidos está el antígeno de los eritrocitos "Xgª", codificado por el gen del locus Xp22.32, y algunas ...
Beatriz Martínez   +7 more
doaj   +2 more sources

Generation and Characterization of a Zebrafish Model for ADGRV1-Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology

open access: yesCells, 2023
Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the ADGRV1 gene, for which currently no treatment options exist.
Merel Stemerdink   +5 more
doaj   +1 more source

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