Results 41 to 50 of about 6,115,203 (305)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Genetic basis for nitrate resistance in Desulfovibrio strains

Frontiers in Microbiology, 2014
Nitrate is an inhibitor of sulfate-reducing bacteria (SRB). In petroleum production sites, amendments of nitrate and nitrite are used to prevent SRB production of sulfide that causes souring of oil wells.
Hannah eKorte, Hannah eKorte, Samuel R Fels, Samuel R Fels, Geoffrey A Christensen, Geoffrey A Christensen, Morgan N Price, Morgan N Price, Jennifer V Kuehl, Jennifer V Kuehl, Grant M Zane, Grant M Zane, Adam M Deutschbauer, Adam M Deutschbauer, Adam P Arkin, Adam P Arkin, Adam P Arkin, Judy D Wall, Judy D Wall, Judy D Wall   +19 more
doaj   +1 more source

A realization of a quasi-random walk for atoms in time-dependent optical potentials

, 2015
We consider the time dependent dynamics of an atom in a two-color pumped cavity, longitudinally through a side mirror and transversally via direct driving of the atomic dipole.
Genes, C., Hinkel, T., Ritsch, H.
core   +2 more sources

The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]

, 2008
Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Passel, M.W.J., van, Marri, P.R., Ochman, H.   +2 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Investigación de dos casos complejos de relación biológica

Iatreia, 2010
Presentamos dos casos complejos de investigación de la relación biológica con un diagnóstico conclusivo. El primero corresponde al caso de una menor sin madre, con presunto padre fallecido y como referencias solo se disponía de la presunta abuela paterna
Diana de Aguirre, Juan José Builes Gómez, Andrea de Manrique, Yesith de Puerto Parra, Leonor de Gusmão, M. L. Bravo   +5 more
doaj  

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

Frontiers in Pharmacology
AimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng, Shuang Zheng, Shuang Zheng, Yin Wang, Shuainan Tang, Yuntao Guo, Duan Ma, Xin Jiang   +7 more
doaj   +1 more source

An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits

Nature Communications, 2017
Mechanisms of neural processing can only be understood by revealing patterns of connectivity among the cellular components of the circuit. Here the authors report a new genetic toolbox, ‘Optobow’, which enables simultaneous optogenetic activation of ...
Dominique Förster, Marco Dal Maschio, Eva Laurell, Herwig Baier   +3 more
doaj   +1 more source

Protected state enhanced quantum metrology with interacting two-level ensembles

, 2013
Ramsey interferometry is routinely used in quantum metrology for the most sensitive measurements of optical clock frequencies. Spontaneous decay to the electromagnetic vacuum ultimately limits the interrogation time and thus sets a lower bound to the ...
Genes, Claudiu, Ostermann, Laurin, Ritsch, Helmut   +2 more
core   +1 more source

Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria. [PDF]

, 2016
BackgroundWhile the CCA sequence at the mature 3' end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes.
Ardell, David H, Hou, Ya-Ming
core   +3 more sources