Results 41 to 50 of about 4,979,257 (318)

Bayesian mixture modeling of gene‐environment and gene‐gene interactions [PDF]

Genetic Epidemiology, 2009
AbstractWith the advent of rapid and relatively cheap genotyping technologies there is now the opportunity to attempt to identify gene‐environment and gene‐gene interactions when the number of genes and environmental factors is potentially large. Unfortunately the dimensionality of the parameter space leads to a computational explosion in the number of
Wakefield, Jon, De Vocht, Frank, Hung, Rayjean J.   +2 more
openaire   +5 more sources

Why are essential genes essential? - The essentiality of Saccharomyces genes [PDF]

, 2015
Essential genes are defined as required for the survival of an organism or a cell. They are of particular interests, not only for their essential biological functions, but also in practical applications, such as identifying effective drug targets to ...
Zhaojie Zhang, Qun Ren
core   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Investigación de dos casos complejos de relación biológica

Iatreia, 2010
Presentamos dos casos complejos de investigación de la relación biológica con un diagnóstico conclusivo. El primero corresponde al caso de una menor sin madre, con presunto padre fallecido y como referencias solo se disponía de la presunta abuela paterna
Diana de Aguirre, Juan José Builes Gómez, Andrea de Manrique, Yesith de Puerto Parra, Leonor de Gusmão, M. L. Bravo   +5 more
doaj  

An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits

Nature Communications, 2017
Mechanisms of neural processing can only be understood by revealing patterns of connectivity among the cellular components of the circuit. Here the authors report a new genetic toolbox, ‘Optobow’, which enables simultaneous optogenetic activation of ...
Dominique Förster, Marco Dal Maschio, Eva Laurell, Herwig Baier   +3 more
doaj   +1 more source

Genetic basis for nitrate resistance in Desulfovibrio strains

Frontiers in Microbiology, 2014
Nitrate is an inhibitor of sulfate-reducing bacteria (SRB). In petroleum production sites, amendments of nitrate and nitrite are used to prevent SRB production of sulfide that causes souring of oil wells.
Hannah eKorte, Hannah eKorte, Samuel R Fels, Samuel R Fels, Geoffrey A Christensen, Geoffrey A Christensen, Morgan N Price, Morgan N Price, Jennifer V Kuehl, Jennifer V Kuehl, Grant M Zane, Grant M Zane, Adam M Deutschbauer, Adam M Deutschbauer, Adam P Arkin, Adam P Arkin, Adam P Arkin, Judy D Wall, Judy D Wall, Judy D Wall   +19 more
doaj   +1 more source

Acknowledgement to Reviewers of Genes in 2014

, 2015
The editors of Genes would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Genes Editorial Office
core   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Natural diversity-guided catalytic-core chimerism engineers a rapid and inhibitor-tolerant reverse transcriptase

Journal of Biological Engineering
Background Reverse transcriptases (RTs) are essential components of RNA-based molecular technologies, yet their practical performance is often constrained by trade-offs between catalytic speed, thermal stability, and tolerance to inhibitory substances ...
Inês Fonseca Costa, Vânia Ondina Fernandes, Rita Silva Simões, Hélvio Simões, Virgínia Maria Rico Pires, Victor Diogo Alves, João Soeiro Teodoro, Pedro Bule, Carlos Mendes Godinho de Andrade Fontes   +8 more
doaj   +1 more source

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

Frontiers in Pharmacology
AimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng, Shuang Zheng, Shuang Zheng, Yin Wang, Shuainan Tang, Yuntao Guo, Duan Ma, Xin Jiang   +7 more
doaj   +1 more source