Results 41 to 50 of about 4,822,162 (317)

Acknowledgement to Reviewers of Genes in 2015

, 2016
The editors of Genes would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015.
Genes Editorial Office
core   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Natural diversity-guided catalytic-core chimerism engineers a rapid and inhibitor-tolerant reverse transcriptase

Journal of Biological Engineering
Background Reverse transcriptases (RTs) are essential components of RNA-based molecular technologies, yet their practical performance is often constrained by trade-offs between catalytic speed, thermal stability, and tolerance to inhibitory substances ...
Inês Fonseca Costa, Vânia Ondina Fernandes, Rita Silva Simões, Hélvio Simões, Virgínia Maria Rico Pires, Victor Diogo Alves, João Soeiro Teodoro, Pedro Bule, Carlos Mendes Godinho de Andrade Fontes   +8 more
doaj   +1 more source

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

Frontiers in Pharmacology
AimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng, Shuang Zheng, Shuang Zheng, Yin Wang, Shuainan Tang, Yuntao Guo, Duan Ma, Xin Jiang   +7 more
doaj   +1 more source

An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits

Nature Communications, 2017
Mechanisms of neural processing can only be understood by revealing patterns of connectivity among the cellular components of the circuit. Here the authors report a new genetic toolbox, ‘Optobow’, which enables simultaneous optogenetic activation of ...
Dominique Förster, Marco Dal Maschio, Eva Laurell, Herwig Baier   +3 more
doaj   +1 more source

Acknowledgement to Reviewers of Genes in 2013

, 2014
The editors of Genes would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2013.
Genes Editorial Office
core   +1 more source

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Matthews, K R; id_orcid, Graham, S V, Shiels, P G, Barry, J D   +3 more
core   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Estudio genético de la población afrodescendiente del departamento del Chocó con marcadores ligados al cromosoma X

Iatreia, 2010
Los marcadores genéticos tipo microsatélites del Cromosoma X (X-STR) han recibido creciente atención tan sólo en los últimos 10 años. Se ha demostrado su gran capacidad para aclarar casos complejos de parentesco, tales como abuela paterna - nieta ...
Juan José Builes, Marcela López Velásquez, Diana Patricia Aguirre, Leonor de Gusmão, Andrea Jhoanna Manrique Rincón, Yesith Puerto Parra, M. Luisa Judith Bravo   +6 more
doaj  

Genetic basis for nitrate resistance in Desulfovibrio strains

Frontiers in Microbiology, 2014
Nitrate is an inhibitor of sulfate-reducing bacteria (SRB). In petroleum production sites, amendments of nitrate and nitrite are used to prevent SRB production of sulfide that causes souring of oil wells.
Hannah eKorte, Hannah eKorte, Samuel R Fels, Samuel R Fels, Geoffrey A Christensen, Geoffrey A Christensen, Morgan N Price, Morgan N Price, Jennifer V Kuehl, Jennifer V Kuehl, Grant M Zane, Grant M Zane, Adam M Deutschbauer, Adam M Deutschbauer, Adam P Arkin, Adam P Arkin, Adam P Arkin, Judy D Wall, Judy D Wall, Judy D Wall   +19 more
doaj   +1 more source