Results 31 to 40 of about 3,078,517 (268)

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Investigación de dos casos complejos de relación biológica

Iatreia, 2010
Presentamos dos casos complejos de investigación de la relación biológica con un diagnóstico conclusivo. El primero corresponde al caso de una menor sin madre, con presunto padre fallecido y como referencias solo se disponía de la presunta abuela paterna
Diana de Aguirre, Juan José Builes Gómez, Andrea de Manrique, Yesith de Puerto Parra, Leonor de Gusmão, M. L. Bravo   +5 more
doaj  

Natural diversity-guided catalytic-core chimerism engineers a rapid and inhibitor-tolerant reverse transcriptase

Journal of Biological Engineering
Background Reverse transcriptases (RTs) are essential components of RNA-based molecular technologies, yet their practical performance is often constrained by trade-offs between catalytic speed, thermal stability, and tolerance to inhibitory substances ...
Inês Fonseca Costa, Vânia Ondina Fernandes, Rita Silva Simões, Hélvio Simões, Virgínia Maria Rico Pires, Victor Diogo Alves, João Soeiro Teodoro, Pedro Bule, Carlos Mendes Godinho de Andrade Fontes   +8 more
doaj   +1 more source

Genetic basis for nitrate resistance in Desulfovibrio strains

Frontiers in Microbiology, 2014
Nitrate is an inhibitor of sulfate-reducing bacteria (SRB). In petroleum production sites, amendments of nitrate and nitrite are used to prevent SRB production of sulfide that causes souring of oil wells.
Hannah eKorte, Hannah eKorte, Samuel R Fels, Samuel R Fels, Geoffrey A Christensen, Geoffrey A Christensen, Morgan N Price, Morgan N Price, Jennifer V Kuehl, Jennifer V Kuehl, Grant M Zane, Grant M Zane, Adam M Deutschbauer, Adam M Deutschbauer, Adam P Arkin, Adam P Arkin, Adam P Arkin, Judy D Wall, Judy D Wall, Judy D Wall   +19 more
doaj   +1 more source

Bayesian mixture modeling of gene‐environment and gene‐gene interactions [PDF]

Genetic Epidemiology, 2009
AbstractWith the advent of rapid and relatively cheap genotyping technologies there is now the opportunity to attempt to identify gene‐environment and gene‐gene interactions when the number of genes and environmental factors is potentially large. Unfortunately the dimensionality of the parameter space leads to a computational explosion in the number of
Wakefield, Jon, De Vocht, Frank, Hung, Rayjean J.   +2 more
openaire   +5 more sources

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

Frontiers in Pharmacology
AimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng, Shuang Zheng, Shuang Zheng, Yin Wang, Shuainan Tang, Yuntao Guo, Duan Ma, Xin Jiang   +7 more
doaj   +1 more source

An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits

Nature Communications, 2017
Mechanisms of neural processing can only be understood by revealing patterns of connectivity among the cellular components of the circuit. Here the authors report a new genetic toolbox, ‘Optobow’, which enables simultaneous optogenetic activation of ...
Dominique Förster, Marco Dal Maschio, Eva Laurell, Herwig Baier   +3 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Estudio genético de la población afrodescendiente del departamento del Chocó con marcadores ligados al cromosoma X

Iatreia, 2010
Los marcadores genéticos tipo microsatélites del Cromosoma X (X-STR) han recibido creciente atención tan sólo en los últimos 10 años. Se ha demostrado su gran capacidad para aclarar casos complejos de parentesco, tales como abuela paterna - nieta ...
Juan José Builes, Marcela López Velásquez, Diana Patricia Aguirre, Leonor de Gusmão, Andrea Jhoanna Manrique Rincón, Yesith Puerto Parra, M. Luisa Judith Bravo   +6 more
doaj