Results 31 to 40 of about 3,058,847 (268)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Genetic basis for nitrate resistance in Desulfovibrio strains

Frontiers in Microbiology, 2014
Nitrate is an inhibitor of sulfate-reducing bacteria (SRB). In petroleum production sites, amendments of nitrate and nitrite are used to prevent SRB production of sulfide that causes souring of oil wells.
Hannah eKorte, Hannah eKorte, Samuel R Fels, Samuel R Fels, Geoffrey A Christensen, Geoffrey A Christensen, Morgan N Price, Morgan N Price, Jennifer V Kuehl, Jennifer V Kuehl, Grant M Zane, Grant M Zane, Adam M Deutschbauer, Adam M Deutschbauer, Adam P Arkin, Adam P Arkin, Adam P Arkin, Judy D Wall, Judy D Wall, Judy D Wall   +19 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Investigación de dos casos complejos de relación biológica

Iatreia, 2010
Presentamos dos casos complejos de investigación de la relación biológica con un diagnóstico conclusivo. El primero corresponde al caso de una menor sin madre, con presunto padre fallecido y como referencias solo se disponía de la presunta abuela paterna
Diana de Aguirre, Juan José Builes Gómez, Andrea de Manrique, Yesith de Puerto Parra, Leonor de Gusmão, M. L. Bravo   +5 more
doaj  

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

Frontiers in Pharmacology
AimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng, Shuang Zheng, Shuang Zheng, Yin Wang, Shuainan Tang, Yuntao Guo, Duan Ma, Xin Jiang   +7 more
doaj   +1 more source

An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits

Nature Communications, 2017
Mechanisms of neural processing can only be understood by revealing patterns of connectivity among the cellular components of the circuit. Here the authors report a new genetic toolbox, ‘Optobow’, which enables simultaneous optogenetic activation of ...
Dominique Förster, Marco Dal Maschio, Eva Laurell, Herwig Baier   +3 more
doaj   +1 more source

Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey

eLife, 2020
Retinal axon projections form a map of the visual environment in the tectum. A zebrafish larva typically detects a prey object in its peripheral visual field.
Dominique Förster, Thomas O Helmbrecht, Duncan S Mearns, Linda Jordan, Nouwar Mokayes, Herwig Baier   +5 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

GEIRA: gene-environment and gene–gene interaction research application [PDF]

European Journal of Epidemiology, 2011
The GEIRA (Gene-Environment and Gene-Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene-gene interaction analysis. It implements concepts of both additive and multiplicative interaction as well as calculations based on dominant, recessive and co-dominant genetic models ...
Ding, Bo, Källberg, Henrik, Klareskog, Lars, Padyukov, Leonid, Alfredsson, Lars   +4 more
openaire   +3 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source