Results 11 to 20 of about 3,058,847 (268)
Theory in Biosciences, 2008 In order to describe a cell at molecular level, a notion of a "gene" is neither necessary nor helpful. It is sufficient to consider the molecules (i.e., chromosomes, transcripts, proteins) and their interactions to describe cellular processes. The downside of the resulting high resolution is that it becomes very tedious to address features on the ...
Sonja J. Prohaska, Peter F. Stadler
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Gene Complexity and Gene Duplicability [PDF]
Current Biology, 2005 Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higher rate of gene duplication than prokaryotes do [6, 7]. Because gene duplication is the primary source of new genes [], the average gene complexity in a genome
He, Xionglei, Zhang, Jianzhi
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Gene Activation and Gene Silencing [PDF]
Plant Physiology, 2001 Twenty-five years ago the field of eukaryotic gene regulation was in its infancy. Paradigms driving experiments came primarily from work with prokaryotes and the phage that infected them (12). These paradigms, pioneered by Jacob and Monod, were that genes contained promoter sequences to which ...
V L, Chandler, H, Vaucheret
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FlyBase: genes and gene models [PDF]
Nucleic Acids Research, 2004 FlyBase (http://flybase.org) is the primary repository of genetic and molecular data of the insect family Drosophilidae. For the most extensively studied species, Drosophila melanogaster, a wide range of data are presented in integrated formats.
Rachel A. Drysdale, Madeline A. Crosby
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Analysis of Gene‐Gene Interactions [PDF]
Current Protocols in Human Genetics, 2011 AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
Diane, Gilbert-Diamond, Jason H, Moore
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Gene Dosage and Gene Duplicability [PDF]
Genetics, 2008 Abstract The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more ...
Wenfeng, Qian, Jianzhi, Zhang
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The Epidermis: Genes On – Genes Off
Journal of Investigative Dermatology, 1997 The epidermal keratinocyte stem cell is distinguished by a relatively undifferentiated phenotype and an ability to proliferate. As part of a carefully orchestrated process, the offspring of these stem cells lose the ability to proliferate and begin a process of morphologic and biochemical transformation that results in their conversion into corneocytes.
Eckert, Richard L. +3 more
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Gene-Gene and Gene-Environment Interactions in Mild Hyperhomocysteinemia [PDF]
Pathophysiology of Haemostasis and Thrombosis, 2003 Mild/moderate hyperhomocysteinemia (HHcy), a highly prevalent condition, is independently associated with an increased risk of arterial and venous thromboembolic diseases. Early reports of the association of mild/moderate HHcy with juvenile venous thromboembolism have shown familiarity for HHcy in relatives of index cases with thrombosis.
D'Angelo, Armando +2 more
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Iatreia, 2010 Los marcadores del cromosoma X se han utilizado en identificación humana y en pruebas de paternidad desde la década de los setenta, entre los más conocidos está el antígeno de los eritrocitos "Xgª", codificado por el gen del locus Xp22.32, y algunas ...
Beatriz Martínez +7 more
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Cells, 2023 Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the ADGRV1 gene, for which currently no treatment options exist.
Merel Stemerdink +5 more
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