Results 21 to 30 of about 159,072 (309)

Successful treatment of a pure red-cell aplasia patient with γδT cells and clonal TCR gene rearrangement: A case report

Frontiers in Immunology, 2023
Pure red-cell aplasia (PRCA) is a syndrome associated with reduced erythroid precursors. This report presents the case of an elderly PRCA patient with significantly proliferated γδT cells and clonal T-cell receptor (TCR) gene rearrangement.
Xian Li, Xinyi Zhu, Xiaohong Zhang, Weiqin Wang   +3 more
doaj   +1 more source

PD-1/PD-L1 inhibitor activity in patients with gene-rearrangement positive non-small cell lung cancer—an IMMUNOTARGET case series [PDF]

, 2022
BACKGROUND: Prior IMMUNOTARGET registry data had suggested that responses to immune [anti PD(L)1] monotherapy in gene-arranged non-small cell lung cancer (NSCLC) were rare or absent, depending on the specific oncogene.
Gautschi, Oliver, Mushtaq, Rao, Cortot, Alexis B., Camidge, D Ross, Cortot, Alexis B, Mazieres, Julien, Camidge, D. Ross   +6 more
core   +1 more source

Case Report: Complete Response to Nivolumab in a Patient With Programmed Cell Death 1 Ligand 1-Positive and Multiple Gene-Driven Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitor-Resistant Lung Adenocarcinoma

Frontiers in Immunology, 2021
Multiple gene-driven programmed cell death 1 ligand 1 (PD-L1)-expressing non-small-cell lung cancer (NSCLC) is very rare. Previous studies have shown that patients with NSCLC with anaplastic lymphoma kinase (ALK) gene rearrangement rarely benefit from PD-
Wen Dong, Pengfei Lei, Xin Liu, Qin Li, Xiangyang Cheng   +4 more
doaj   +1 more source

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T.   +5 more
core   +1 more source

Prevalence and Clinical Impact of Concomitant Mutations in Anaplastic Lymphoma Kinase Rearrangement Advanced Non-small-Cell Lung Cancer (Guangdong Association of Thoracic Oncology Study 1055)

Frontiers in Oncology, 2020
Background: In patients with anaplastic lymphoma kinase (ALK) rearrangement-positive advanced non–small-cell lung cancer (NSCLC), ALK inhibitors are now the standard treatment, but their clinical efficacy varies widely for each patient.
Meichen Li, Xue Hou, Chengzhi Zhou, Weineng Feng, Guanming Jiang, Hao Long, Shuang Yang, Jing Chen, Na Wang, Kaicheng Wang, Likun Chen   +10 more
doaj   +1 more source

Insights into the Evolution of Aphid Mitogenome Features from New Data and Comparative Analysis

Animals, 2022
The complete mitochondrial genomes and their rearrangement patterns can provide useful information for inferring evolutionary history of organisms. Aphids are one of the insect groups with some unique mitogenome features.
Hui Zhang, Congcong Lu, Qian Liu, Tianmin Zou, Gexia Qiao, Xiaolei Huang   +5 more
doaj   +1 more source

A method for computing an inventory of metazoan mitochondrial gene order rearrangements

BMC Bioinformatics, 2011
Background Changes in the order of mitochondrial genes are a good source of information for phylogenetic investigations. Phylogenetic hypotheses are often supported by parsimonious mitochondrial gene order rearrangement scenarios. CREx is a heuristic for
Middendorf Martin, Bernt Matthias
doaj   +1 more source

Phylogenetic reconstruction with gene rearrangements and gene losses [PDF]

2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2010
Reconstructing phylogenies from gene-order data has become very attractive in the research of evolution these years. So far, most methods can only treat genomes with equal gene contents with each gene appearing exactly once in each genome. In this paper, we propose a new distance measurement for genomes with inversions and insertions/deletions that ...
Yiwei Zhang, Fei Hu, Jijun Tang
openaire   +1 more source

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. [PDF]

, 2010
BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa).
P T Scardino, Reid, A. H. M., D Brewer, Clark, J, S Edwards, H Møller, Kovacs, G., Gerald, W. L., Cuzick, J, Ambroisine, L., Cooper, C S, D M Berney, G Attard, de Bono, J S, J Cuzick, Cuzick, J., Reid, A H M, C S Cooper, Foster, C. S., Fletcher, A., Scardino, P. T., Fisher, G, Møller, H, Brewer, D, G Fisher, C S Foster, A Fletcher, Scardino, P T, Flohr, P., Scardino, PT, J S de Bono, de Bono, J. S., V E Reuter, Reuter, V. E., Cooper, CS, Edwards, S., de Bono, JS, G Kovacs, J Clark, Brewer, D., Attard, G, Fletcher, A, P Flohr, Flohr, P, Berney, D. M., Moller, H.; id_orcid, A H M Reid, Attard, G., Kovacs, G, Berney, DM, Edwards, S, L Ambroisine, Fisher, G., Foster, C S, Reuter, V E, Clark, J., Gerald, WL, Transatlantic Prostate Group, W L Gerald, Ambroisine, L, Reid, AHM, Foster, CS, Reuter, VE, Cooper, C. S., Gerald, W L, Berney, D M   +65 more
core   +1 more source

V_H replacement in rearranged immunoglobulin genes [PDF]

, 2005
Examples suggesting that all or part of the V_H segment of a rearranged V_HDJ_H may be replaced by all or part of another V_H have been appearing since the 1980s ...
Darlow, J.M., John M. Darlow, David I. Stott, Stott, D.I.   +3 more
core   +1 more source