Results 11 to 20 of about 264,764 (308)
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription [PDF]
, 1991 Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highly sensitive polymerase chain reaction assays for Ig gene rearrangement and unrearranged Ig gene segment transcription to ...
Baltimore, David +2 more
core +5 more sources
Insights into the Evolution of Aphid Mitogenome Features from New Data and Comparative Analysis
Animals, 2022 The complete mitochondrial genomes and their rearrangement patterns can provide useful information for inferring evolutionary history of organisms. Aphids are one of the insect groups with some unique mitogenome features.
Hui Zhang +5 more
doaj +1 more source
A method for computing an inventory of metazoan mitochondrial gene order rearrangements
BMC Bioinformatics, 2011 Background Changes in the order of mitochondrial genes are a good source of information for phylogenetic investigations. Phylogenetic hypotheses are often supported by parsimonious mitochondrial gene order rearrangement scenarios. CREx is a heuristic for
Middendorf Martin, Bernt Matthias
doaj +1 more source
Frontiers in Oncology, 2020 Background: In patients with anaplastic lymphoma kinase (ALK) rearrangement-positive advanced non–small-cell lung cancer (NSCLC), ALK inhibitors are now the standard treatment, but their clinical efficacy varies widely for each patient.
Meichen Li +10 more
doaj +1 more source
Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma [PDF]
, 2010 We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript.
Jakovljević, Gordana +6 more
core +1 more source
A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter [PDF]
, 2017 Introduction: While most transcripts arising from the human T Cell Receptor locus reflect fully rearranged genes, several germline transcripts have been identified. We describe a new germline transcript arising from the human TCRB locus.
Abarrategui +33 more
core +2 more sources
Blood Advances, 2016 : We report here on a case of ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia (B-ALL) that has acquired a BCR-ABL1 gene rearrangement as a subclonal change.
Karen A. Dun +5 more
doaj +1 more source
Pulmonary Medicine, 2020 Background. Under the National Comprehensive Cancer Network (NCCN) guidelines for non-small-cell lung carcinoma (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangement is required to be assessed.
Didik S. Heriyanto +8 more
doaj +1 more source
Programmed Gene Rearrangements Altering Gene Expression
Science, 1987 Programmed gene rearrangements are used in nature to alter gene copy number (gene amplification and deletion), to create diversity by reassorting gene segments (as in the formation of mammalian immunoglobulin genes), or to control the expression of a set of genes that code for the same function (such as surface antigens).
Borst, P, Greaves, D
openaire +3 more sources
Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. [PDF]
, 2018 Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression. Despite the distinct findings, accurate diagnosis of fibrolamellar carcinoma continues to be a challenge.
Alves, Venancio Af +27 more
core +1 more source