Results 11 to 20 of about 2,645 (218)

Phylogenetic reconstruction with gene rearrangements and gene losses [PDF]

2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2010
Reconstructing phylogenies from gene-order data has become very attractive in the research of evolution these years. So far, most methods can only treat genomes with equal gene contents with each gene appearing exactly once in each genome. In this paper, we propose a new distance measurement for genomes with inversions and insertions/deletions that ...
Yiwei Zhang, Fei Hu, Jijun Tang
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BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia

Blood Advances, 2016
: We report here on a case of ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia (B-ALL) that has acquired a BCR-ABL1 gene rearrangement as a subclonal change.
Karen A. Dun, Rob Vanhaeften, Tracey J. Batt, Louise A. Riley, Giuseppe Diano, Jan Williamson   +5 more
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The Prevalence of the EML4-ALK Fusion Gene in Cytology Specimens from Patients with Lung Adenocarcinoma

Pulmonary Medicine, 2020
Background. Under the National Comprehensive Cancer Network (NCCN) guidelines for non-small-cell lung carcinoma (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangement is required to be assessed.
Didik S. Heriyanto, Ika Trisnawati, Evan G. Kumara, Vincent Laiman, Fara S. Yuliani, Auliya S. B. Sumpono, Rita Cempaka, Marcellus, Eko Budiono   +8 more
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Lateral gene transfer, rearrangement, reconciliation [PDF]

BMC Bioinformatics, 2013
Models of ancestral gene order reconstruction have progressively integrated different evolutionary patterns and processes such as unequal gene content, gene duplications, and implicitly sequence evolution via reconciled gene trees. These models have so far ignored lateral gene transfer, even though in unicellular organisms it can have an important ...
Patterson, Murray, Szöllősi, Gergely, Daubin, Vincent, Tannier, Eric   +3 more
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Maternal acute lymphoctic leukemia with rearrangement of the mixed lineage leukemia gene occurring during pregnancy

Hematology/Oncology and Stem Cell Therapy, 2009
Acute lymphoblastic leukemia (ALL) is a relatively rare disease during pregnancy, accounting for about 15% of all cases of pregnancy-associated leukemia.
Mahmoud Aljurf, Amr Nassar, Abu Jafar Saleh, Fahed Almhareb, Hazzaa Alzahrani, Claudia Walter, Mohammad Bakr, Syed Osman Ahmed, Naeem Chaudhri   +8 more
doaj   +1 more source

First Report on Mitochondrial Gene Rearrangement in Non-Biting Midges, Revealing a Synapomorphy in Stenochironomus Kieffer (Diptera: Chironomidae)

Insects, 2022
(1) Background: Gene rearrangement of mitochondrial genome, especially those with phylogenetic signals, has long fascinated evolutionary biologists. The synapomorphic gene rearrangements have been identified across multiple orders and at many different ...
Chen-Guang Zheng, Zheng Liu, Yan-Min Zhao, Yang Wang, Wen-Jun Bu, Xin-Hua Wang, Xiao-Long Lin   +6 more
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Clinical and computed tomography characteristics of non‐small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR‐negative lung cancer

Thoracic Cancer, 2019
Background The study was conducted to evaluate the clinical and computed tomography (CT) findings of non‐small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non‐ALK/EGFR (no genetic abnormalities ...
Mio Mori, Hideyuki Hayashi, Minoru Fukuda, Sumihisa Honda, Takeshi Kitazaki, Kazuto Shigematsu, Naohiro Matsuyama, Mayumi Otsubo, Takeshi Nagayasu, Mikiko Hashisako, Kazuhiro Tabata, Masataka Uetani, Kazuto Ashizawa   +12 more
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Genome rearrangement with gene families [PDF]

Bioinformatics, 1999
Abstract Motivation: The theory and practice of genome rearrangement analysis breaks down in the biologically widespread contexts where each gene may be present in a number of copies, not necessarily contiguous. In some of these contexts it is, however, appropriate to ask which members of each gene family in two genomes G and H, lengths ...
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Immunohistochemistry and fluorescence in-situ hybridization study for detection of anaplastic lymphoma kinase gene rearrangement in nonsmall cell lung carcinoma

Egyptian Journal of Chest Disease and Tuberculosis, 2018
Patients and methods Testing for Anaplastic Lymphoma Kinas (ALK) rearrangement is now recommended for selection of lung cancer patients targeted for Tyrosine-kinase inhibitors (Crizotimib).
Mohamed Hantera, Ibrahim S Ibrahim, Amira Y Abdelnaby, Ayman El Saka, Heba F Harras   +4 more
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Case Report: Patient With Lung Adenocarcinoma With ALK-HLA-DRB1 Rearrangement Shows Impressive Progression-Free Survival After Sequential Crizotinib and Ceritinib Treatment

Frontiers in Oncology, 2022
The anaplastic lymphoma kinase (ALK) gene rearrangement is a driving mutation that underlies about 5-6% of non-small cell lung cancer (NSCLC) cases. Lung cancers that are ALK gene rearrangement-positive can be effectively treated with ALK inhibitors ...
Peng Gao, Kangning Tang, Yuqiu Hao, Wei Li, Xuejiao Lv, Dapeng Li, Yuxi Jia   +6 more
doaj   +1 more source