Results 61 to 70 of about 159,072 (309)

Detection of t(8;14) c-myc/IgH gene rearrangement by long-distance polymerase chain reaction in patients with diffuse large B-cell lymphoma

Hematology/Oncology and Stem Cell Therapy, 2016
Objective/background: Specific chromosomal translocations are found in human leukemias and lymphomas. These translocations are closely related to particular histological and immunological phenotypes. In Burkitt's lymphoma, translocation t(8;14)(q24;q32),
Arezoo Kiaei, Habib Onsori, Aylar Alijani, Sasan Andalib, Saeid Ghorbian, Ebrahim Sakhinia   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The mitochondrial genome of a social aphid, Pseudoregma bambucicola (Hemiptera: Aphididae: Hormaphidinae)

Mitochondrial DNA. Part B. Resources, 2019
In this study, the complete mitochondrial genome of the social aphid Pseudoregma bambucicola was assembled and annotated. The genome spans 16,631 bp in length with a high A + T content (85.1%), containing 13 protein-coding genes, 22 tRNA genes, two rRNA ...
Hui Zhang, Jun Deng, Qian Liu, Xiaolei Huang   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Phenomenon of Gene Rearrangement is Frequently Associated with TP53 Mutations and Poor Disease-Free Survival in Hepatocellular Carcinoma

, 2021
Fu He,1,2 Kangjian Song,1,2 Ge Guan,3 Junyu Huo,1,2 Yang Xin,1 Tianxiang Li,3 Chao Liu,1 Qingwei Zhu,1,2 Ning Fan,1 Yuan Guo,1 Liqun Wu1 1Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, People’s ...
He F, Song K, Huo J, Wu L, Guan G, Li T, Guo Y, Fan N, Liu C, Zhu Q, Xin Y   +10 more
core  

Genealogy-based methods for inference of historical recombination and gene flow and their application in Saccharomyces cerevisiae [PDF]

, 2012
Genetic exchange between isolated populations, or introgression between species, serves as a key source of novel genetic material on which natural selection can act.
Brem, Rachel B., Jenkins, Paul A, Paul A Jenkins, Yun S Song, Song, Yun S., Song, Yun S, Rachel B. Brem (114263), Jenkins, Paul, Yun S. Song (109761), Paul A. Jenkins (109759), Brem, Rachel B, Rachel B Brem   +11 more
core   +1 more source

Annotation of gene loci and analysis of expression diversity in sheep immunoglobulin

Frontiers in Immunology
As an important livestock species, sheep exhibit remarkable environmental adaptability. Immunoglobulins, expressed by B cells, are among the most crucial effector molecules in adaptive immunity.
Mingli Wu, Fuwen Chen, Xiaoqin Tang, Jingxuan Li, Haidong Zhao, Yuelang Zhang   +5 more
doaj   +1 more source

Clinicopathological practice in the differential diagnosis of mucoepidermoid carcinoma from neoplasms with mucinous component

Chronic Diseases and Translational Medicine, 2023
Background The differential diagnosis of mucoepidermoid carcinoma (MEC) from neoplasm undergoing mucinous features brings more pitfalls to pathologists.
Yuelu Zhu, Yan Li, Lei Guo, Wenbin Li, Jiali Mu, Haifeng Zhang, Xin Li, Jianming Ying, Haizhen Lu   +8 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source