Results 81 to 90 of about 159,072 (309)

B- And T-Cell Gene Rearrangement Analysis In Lymphoid Neoplasms

, 2021
The significance of positive immunoglobulin (IG) or T-cell receptor (TCR) gene rearrangement studies in the context of otherwise normal ancillary findings is unknown.
Mendoza, Hadrian
core  

Recombination and population structure in salmonella enterica [PDF]

, 2011
Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals. Although its population structure was long described as clonal, based on high linkage disequilibrium between loci typed by enzyme ...
Street, T, Bowden, R., Anjum, Muna F., Xavier Didelot, Falush Daniel, Donnelly Peter, Didelot, X., Anjum, MF, Donelly, P., McVean, G., Gil McVean, Vartul Sangal, Didelot, X, Bowden, Rory, Anjum Muna F., Donnelly, Peter, Anjum, Muna, Achtman, Mark, Sangal, V, Spencer, C., Falush, Daniel, Muna F. Anjum, Sangal, V., Tanya Golubchik, Anjum, M., Achtman, M., Daniel Falush, Peter Donnelly, McVean, G, Didelot, Xavier, Teresa Street, Mark Achtman, Bowden Rory, Spencer, Chris, Didelot Xavier, Sangal, Vartul, Street, T., Spencer Chris, McVean Gil, Spencer, C, Donelly, Peter, Chris Spencer, Donnelly, P, Street, Teresa, Street Teresa, Golubchik Tanya, Golubchik, T., Achtman Mark, Golubchik, Tanya, Falush, D, Rory Bowden, Bowden, R, McVean, Gilean, Sangal Vartul, McVean, Gil, Golubchik, T, Falush, D. ; https://orcid.org/, Muna F Anjum, Achtman, M   +58 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia

Advances in Hematology, 2009
In this study, Forty-one out of fifty-seven Tunisian children with B-lineage acute lymphoblastic leukemia (B-ALL), and without cytogenetically detectable recurrent abnormalities at the time of the diagnosis, were evaluated by fluorescence in situ ...
Abir Gmidène, Hatem Elghezal, Hlima Sennana, Yosra Ben Youssef, Balkiss Meddeb, Moez Elloumi, Abderrahim Khlif, Ali Saad   +7 more
doaj   +1 more source

Mechanisms of gene rearrangement in 13 bothids based on comparison with a newly completed mitogenome of the threespot flounder, Grammatobothus polyophthalmus (Pleuronectiformes: Bothidae)

BMC Genomics, 2019
Background The mitogenomes of 12 teleost fish of the bothid family (order Pleuronectiformes) indicated that the genomic-scale rearrangements characterized in previous work.
Hairong Luo, Xiaoyu Kong, Shixi Chen, Wei Shi   +3 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Human Papillomaviruses in Buschke-Lowenstein Tumors: Physical State of the DNA and Identification of a Tandem Duplication in the Noncoding Region of a Human Papillomavirus 6 Subtype [PDF]

, 1986
Six Buschke-Löwenstein tumors, i.e., highly differentiated squamous cell tumors of the genital region, were shown to contain human papillomavirus 6 (HPV 6) or HPV 11 genomes.
Boshart, Michael, Hausen, Harald zur
core  

T cell receptor [beta]-chain gene rearrangement without [gamma]-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding

, 1990
T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor [beta]-chain gene in the absence of rearrangement of the [gamma]-chain gene.
Ho, Vincent C., Elder, James T., Hanson, Curtis A., Hansen, Erik R., Baadsgaard, Ole, Vejlsgaard, Gunhild L., Cooper, Kevin D.   +6 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source