Results 91 to 100 of about 264,764 (308)

Assessing the robustness of parsimonious predictions for gene neighborhoods from reconciled phylogenies [PDF]

, 2015
The availability of a large number of assembled genomes opens the way to study the evolution of syntenic character within a phylogenetic context. The DeCo algorithm, recently introduced by B{\'e}rard et al.
Chauve, Cedric, Ponty, Yann, Rajaraman, Ashok   +2 more
core   +5 more sources

ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia

Advances in Hematology, 2009
In this study, Forty-one out of fifty-seven Tunisian children with B-lineage acute lymphoblastic leukemia (B-ALL), and without cytogenetically detectable recurrent abnormalities at the time of the diagnosis, were evaluated by fluorescence in situ ...
Abir Gmidène, Hatem Elghezal, Hlima Sennana, Yosra Ben Youssef, Balkiss Meddeb, Moez Elloumi, Abderrahim Khlif, Ali Saad   +7 more
doaj   +1 more source

Mechanisms of gene rearrangement in 13 bothids based on comparison with a newly completed mitogenome of the threespot flounder, Grammatobothus polyophthalmus (Pleuronectiformes: Bothidae)

BMC Genomics, 2019
Background The mitogenomes of 12 teleost fish of the bothid family (order Pleuronectiformes) indicated that the genomic-scale rearrangements characterized in previous work.
Hairong Luo, Xiaoyu Kong, Shixi Chen, Wei Shi   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Small Family of Elements with Long Inverted Repeats is Located Near Sites of Developmentally Regulated DNA Rearrangement in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1994
Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans. The micronuclear junctions and the macronuclear product of a developmentally regulated DNA rearrangement in ...
Berger, Patricia J., Catt, Diana M., Ellingson, Jay Lee Edward, Karrer, Kathleen M., Wells, John M.   +4 more
core   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Parking functions, labeled trees and DCJ sorting scenarios [PDF]

, 2009
In genome rearrangement theory, one of the elusive questions raised in recent years is the enumeration of rearrangement scenarios between two genomes.
A. Bergeron, A. McLysaght, A.C. Siepel, A.G. Konheim, A.W. Xu, D. Sankoff, D. Sankoff, E. Barcucci, I. Miklós, I. Miklós, M. Ozery-flato, M.D.V. Braga, P. Pevzner, R.P. Stanley, R.P. Stanley, R.P. Stanley, S. Bérard, S. Yancopoulos, Y. Ajana, Y. Diekmann   +19 more
core   +5 more sources

Recurrent CIC-rearranged sarcoma of central nervous system: a clinicopathological case report

Frontiers in Oncology
CIC-rearranged sarcoma (CRS) is a subgroup of small round blue cell tumors similar to Ewing’s sarcoma but lacking the EWSR1 gene translocation. It is characterized by a CIC gene rearrangement on chromosome 19q13, with the most common partner gene being ...
Shan Jiang, Shan Jiang, Shan Jiang, Shan Jiang, Kay Ka-Wai Li, Jingqi Hu, Jingqi Hu, Yun Guan, Yun Guan, Yun Guan, Rui-Ze Zhu, Rui-Ze Zhu, Rui-Ze Zhu, Rui-Ze Zhu, Hou-Shi Xu, Hou-Shi Xu, Hou-Shi Xu, Hou-Shi Xu, Mao-Yuan Sun, Mao-Yuan Sun, Mao-Yuan Sun, Mao-Yuan Sun, Bei-Ning Liu, Bei-Ning Liu, Bei-Ning Liu, Bei-Ning Liu, Hui-Hui Chai, Hui-Hui Chai, Hui-Hui Chai, Hui-Hui Chai, Yue Wang, Yue Wang, Yue Wang, Qi-Sheng Tang, Qi-Sheng Tang, Qi-Sheng Tang, Qi-Sheng Tang, Ho-Keung Ng, Zhi-Feng Shi, Zhi-Feng Shi, Zhi-Feng Shi, Zhi-Feng Shi   +41 more
doaj   +1 more source

Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes

Frontiers in Immunology, 2014
While most genes in the mammalian genome are transcribed from both parental chromosomes in cells where they are expressed, approximately 10% of genes are expressed monoallelically, so that any given cell will express either the paternal or maternal ...
Rena eLevin-Klein, Yehudit eBergman
doaj   +1 more source