Results 201 to 210 of about 21,294 (218)

Detection of ALK protein expression in lung squamous cell carcinomas by immunohistochemistry [PDF]

, 2014

core   +1 more source

Case report: Pathological complete response to neoadjuvant brigatinib in stage III non-small cell lung cancer with ALK rearrangement. [PDF]

Front Oncol
Seong H, Kim SH, Kim MH, Cho JS, Kim A, Eom JS.   +5 more
europepmc   +1 more source

Reducing overtreatment of older people near the end of life: the role of hospitals in a culture change [PDF]

, 2018
Alkhouri, Hatem, Cardona, Magnolia, Clark, Justin, Lewis, Ebony, Lovell, Nigel, Stehlik, Paulie   +5 more
core  

RWD134 EFFECT OF ALK-TKI IN ALK-REARRANGED VERSUS ALK-REARRANGED WITH PD-L1 POSITIVE NSCLC: A TARGET TRIAL EMULATION STUDY

Value in Health Regional Issues
Yijin Qiu, Yexin Chen, Yunwu Zhong, Tiantian Zhang   +3 more
openaire   +1 more source

Analysis of the resistance profile of real-world alectinib first-line therapy in patients with ALK rearrangement-positive advanced non-small cell lung cancer using organoid technology in one case of lung cancer. [PDF]

J Thorac Dis
Xie Y, Zhang Y, Wu Y, Xie X, Lin X, Tang Q, Zhou C, Xie Z.   +7 more
europepmc   +1 more source

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Treatment of advanced ALK-rearranged NSCLC following second-generation ALK–TKI failure

Expert Review of Anticancer Therapy, 2023
Anaplastic lymphoma kinase (ALK) gene rearrangement is detected in approximately 3-5% of non-small cell lung cancer (NSCLC) cases. Tyrosine kinase inhibitors (TKIs) targeting ALK rearrangement (ALK-TKIs) have shown significant efficacy and improved the survival of patients with NSCLC exhibiting ALK rearrangement.
Akito, Fukuda, Tatsuya, Yoshida
openaire   +2 more sources

Treatment and detection of ALK-rearranged NSCLC

Lung Cancer, 2013
The recent approval of crizotinib for the treatment of anaplastic lymphoma kinase (ALK)-rearranged advanced non-small cell lung cancer (NSCLC) in the US and other countries has provoked intense interest in ALK rearrangements as oncogenic drivers, and promises to revolutionise the way in which NSCLC is diagnosed and treated.
Peters, Solange, Taron, Miquel, Bubendorf, Lukas, Blackhall, Fiona, Stahel, Rolf   +4 more
openaire   +2 more sources

Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas

American Journal of Surgical Pathology, 2011
A subset (1% to 5%) of non-small-cell lung carcinomas harbors the EML4-ALK fusion gene. Data from previous studies on the histomorphology of ALK-rearranged lung cancer are inconsistent, and the specific histologic parameters that characterize this subset and how accurately such parameters predict underlying ALK abnormality remain uncertain.
Akihiko, Yoshida, Koji, Tsuta, Harumi, Nakamura, Takashi, Kohno, Fumiaki, Takahashi, Hisao, Asamura, Ikuo, Sekine, Masashi, Fukayama, Tatsuhiro, Shibata, Koh, Furuta, Hitoshi, Tsuda   +10 more
openaire   +2 more sources

Native and rearranged ALK copy number and rearranged ALK cell count in NSCLC: Implications for ALK inhibitor therapy.

Journal of Clinical Oncology, 2012
7534 Background: ALK rearranged NSCLC responds well to ALK inhibitors. Clinically, >15% cells showing rearrangements by break-apart FISH classifies tumors as ALK(+). Native ALK copy number gain has also been reported. We explored the significance of native and rearranged ALK copy number on crizotinib outcomes and whether >15% reflected a clear ...
D. Ross Camidge, Margaret Skokan, Porntip Kiatsimkul, Barbara Helfrich, Nathan Schulte, DeLee Maxson, Dara L Aisner, Wilbur A. Franklin, Robert Charles Doebele, Marileila Varella-Garcia   +9 more
openaire   +1 more source

Strategies in ALK Rearranged NSCLC Patients

2014
ALK-fusion positive (ALK+) NSCLC is estimated to account for 2–5 % of all lung cancer cases which translates to an incidence of more than 60,000 patients with this molecular subtype annually worldwide. The first step to treatment is accurate identification of the ALK fusion gene in the diagnostic biopsy. The gold standard objective method for detection
openaire   +2 more sources