Results 21 to 30 of about 21,294 (218)

Endometrial cancer with an EML4-ALK rearrangement [PDF]

Molecular Case Studies, 2018
An 85-yr-old woman was diagnosed with endometrial adenocarcinoma, endometrioid type. Imaging studies showed a large tumor distending the endometrial canal without evidence of local invasion or extrauterine disease. A hysterectomy was performed, followed by microscopic examination of longitudinal tissue sections.
Craig, Jeffrey W., Quade, Bradley J., Muto, Michael G., MacConaill, Laura E.   +3 more
openaire   +2 more sources

The molecular detection and clinical significance of ALK rearrangement in selected advanced non-small cell lung cancer: ALK expression provides insights into ALK targeted therapy. [PDF]

PLoS ONE, 2014
BACKGROUND: This study aimed to elucidate clinical significance of anaplastic lymphoma kinase (ALK) rearrangement in selected advanced non-small cell lung cancer (NSCLC), to compare the application of different ALK detection methods, and especially ...
Ning-Ning Zhang, Yu-Tao Liu, Li Ma, Lin Wang, Xue-Zhi Hao, Zheng Yuan, Dong-Mei Lin, Dan Li, Yu-Jie Zhou, Hua Lin, Xiao-Hong Han, Yan Sun, Yuankai Shi   +12 more
doaj   +1 more source

Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report. [PDF]

, 2015
Lung cancer is the leading cause of cancer-associated mortality worldwide, and the mainstay of treatment remains to be personalised therapy. Tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have been reported to exert a ...
Alì, G., Boldrini, L., Chella, A., Davini, F., Fontanini, G., Lupi, C., Mussi, A., Niccoli, C., Proietti, A.   +8 more
core   +1 more source

Anaplastic Lymphoma Kinase Immunocytochemistry on Cell-Transferred Cytologic Smears of Lung Adenocarcinoma [PDF]

, 2015
Background: Anaplastic lymphoma kinase (ALK) immunohistochemical staining on formalin-fixed paraffin-embedded tissue or cell blocks (CB) has been reported as an effective alternative to fluorescence hybridization in situ (FISH) for the detection of ALK ...
Cheng, Liang, Cramer, Harvey M., Jones, Kelly J., Randolph, Melissa L., Wu, Howard H., Zhang, Chen   +5 more
core   +1 more source

Pulmonary Sarcomatoid Carcinoma with ALK Rearrangement: Frequency, Clinical-Pathologic Characteristics, and Response to ALK Inhibitor

Translational Oncology, 2017
PURPOSE: The incidence of anaplastic lymphoma kinase (ALK) rearrangement in pulmonary sarcomatoid carcinoma (PSC) is controversial. In this study, we aimed to reveal the reliable frequency and the clinical-pathologic characteristics of pulmonary ...
Xinru Chen, Yu Zhang, Jiabin Lu, Chunwei Xu, Jianzhong Liang, Fang Wang, Wenyong Sun, Sangao Fang, Jingping Yuan, Huijuan Wang, Hui Wang, Xuewen Liu, Likun Chen   +12 more
doaj   +1 more source

The Prevalence of the EML4-ALK Fusion Gene in Cytology Specimens from Patients with Lung Adenocarcinoma

Pulmonary Medicine, 2020
Background. Under the National Comprehensive Cancer Network (NCCN) guidelines for non-small-cell lung carcinoma (NSCLC), anaplastic lymphoma kinase (ALK) gene rearrangement is required to be assessed.
Didik S. Heriyanto, Ika Trisnawati, Evan G. Kumara, Vincent Laiman, Fara S. Yuliani, Auliya S. B. Sumpono, Rita Cempaka, Marcellus, Eko Budiono   +8 more
doaj   +1 more source

Real-World Data on the Prevalence of Anaplastic Lymphoma Kinase–Positive Non–Small-Cell Lung Cancer in the Middle East and North Africa

JCO Global Oncology, 2021
PURPOSEAnaplastic lymphoma kinase (ALK) gene alterations are potent oncogenic drivers in non–small-cell lung cancer (NSCLC). Tyrosine kinase inhibitors targeting the ALK pathway are effective in treating ALK-positive NSCLC.
Abdul Rahman Jazieh, Rabab Gaafar, Hassan Errihani, Hassan Jaafar, Fouad Al Dayel, Abeer A. Bahnassy, Hatem El Kadi, Mohamed Magdy Abdallah, Ghazi Zaatari   +8 more
doaj   +1 more source

Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology [PDF]

, 2017
Background: ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular
A Cesano, Adriana Cruvinel Carloni, Adriane F. Evangelista, AP Becker, AS Crystal, AT Shaw, Cristovam Scapulatempo-Neto, DR Camidge, DW-S Wong, EL Kwak, EM Gaughan, FH Wilson, Flávia E. de Paula, I Dagogo-Jack, Iberê Cauduro Soares, J Wu, JM Heuckmann, Jose Elias Miziara, JS Reis-Filho, K McKeage, K Rikova, K Takeuchi, LS Yamane, M Soda, Maicon F. Zanon, Maressa Ferreira-Neto, Mariana Andozia Morini, ME Lira, MM Kulkarni, MW Wynes, Pedro de Marchi, R Roskoski, Rui M. Reis, S-H Jung, SM Ali, SW Morris, T-M Rogers, YP Mossé   +37 more
core   +2 more sources

Immunohistochemistry and fluorescence in-situ hybridization study for detection of anaplastic lymphoma kinase gene rearrangement in nonsmall cell lung carcinoma

Egyptian Journal of Chest Disease and Tuberculosis, 2018
Patients and methods Testing for Anaplastic Lymphoma Kinas (ALK) rearrangement is now recommended for selection of lung cancer patients targeted for Tyrosine-kinase inhibitors (Crizotimib).
Mohamed Hantera, Ibrahim S Ibrahim, Amira Y Abdelnaby, Ayman El Saka, Heba F Harras   +4 more
doaj   +1 more source

ALK‐rearranged squamous cell carcinoma of the lung [PDF]

Thoracic Cancer, 2021
AbstractBackgroundALK rearrangement is a very rare subset of squamous cell carcinoma (SCC) and one of the clinical features in patients is lack of data. Here, we report eight patients diagnosed with SCC of the lung harboring ALK rearrangement.MethodsWe collected primary NSCLC samples at the Beijing Chest Hospital between January 2012 and December 2018 ...
Qiyi Meng, Yujie Dong, Hong Tao, Liang Shi, Li Tong, Junfang Tang, Shucai Zhang, Zhe Liu   +7 more
openaire   +3 more sources