Results 31 to 40 of about 21,294 (218)

Steric Control of Geminal Lewis Pair Behavior: Frustration Induced Dyotropic Rearrangement [PDF]

, 2014
A series of methylene-linked boron/nitrogen geminal Lewis pairs were synthesized and the impacts of sterical effect on their chemical behavior were systematically investigated.
Dorkó, Éva, Gáti, Tamás, Holczbauer, Tamás, Mehdi, Hasan, Pápai, Imre, Soós, Tibor, Varga, Eszter   +6 more
core   +1 more source

Prevalence and Clinico-Pathologic Features of ALK Rearrangement Among Adult Filipinos with Non-Small Cell Lung Cancer in a Private Tertiary Care Hospital

Philippine Journal of Pathology, 2022
Introduction. With advancements in the understanding of lung cancer biology, targeted therapy has become the rule rather than the exception. Patients with ALK rearrangements are amenable to therapy with Alectinib and other ALK inhibitors, which has been
Steffanie Charlyne Tamayo, Rebecca Nagtalon, Joanmarie Balolong-Garcia, Yancel Donna Mascardo, Jose Jasper Andal, Daphne Ang, Marcelo Severino Imasa, Rex Michael Santiago   +7 more
doaj   +1 more source

A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases. [PDF]

, 2017
A challenge in precision medicine requires identification of actionable driver mutations. Critical to such effort is the deployment of sensitive and well-validated assays for mutation detection.
Ali, Siraj, Bergsland, Emily K, Bivona, Trever G, Damato, Bertil, Fogh, Shannon, Miller, Vincent A, Urisman, Anatoly, Wang, Victoria E, Wolfe, John, Young, Lauren   +9 more
core   +1 more source

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]

, 2017
Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht, Claeys, Shana, De Preter, Katleen, Denecker, Geertrui, Durinck, Kaat, Kumps, Candy, Speleman, Franki   +6 more
core   +3 more sources

Does ALK-rearrangement predict favorable response to the therapy of bevacizumab plus pemetrexed in advanced non-small-cell lung cancer? Case report and literature review

Clinical and Translational Medicine, 2018
Background Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies.
Zhichao Liu, Youting Bao, Butuo Li, Xindong Sun, Linlin Wang   +4 more
doaj   +1 more source

A case of synchronous multiple primary lung adenocarcinomas harboring epidermal growth factor receptor mutation and anaplastic lymphoma kinase rearrangement successfully treated with combination of osimertinib and alectinib

Respiratory Medicine Case Reports, 2021
Synchronous multiple primary lung cancers (SMPLC) should be distinguished from intrapulmonary metastasis to define the optimal treatment approach. Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are ...
Yukihisa Inoue, Osamu Matsubara, Yumi Ohira, Satoshi Endo, Yasuto Jinn   +4 more
doaj   +1 more source

Clinical and computed tomography characteristics of non‐small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR‐negative lung cancer

Thoracic Cancer, 2019
Background The study was conducted to evaluate the clinical and computed tomography (CT) findings of non‐small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non‐ALK/EGFR (no genetic abnormalities ...
Mio Mori, Hideyuki Hayashi, Minoru Fukuda, Sumihisa Honda, Takeshi Kitazaki, Kazuto Shigematsu, Naohiro Matsuyama, Mayumi Otsubo, Takeshi Nagayasu, Mikiko Hashisako, Kazuhiro Tabata, Masataka Uetani, Kazuto Ashizawa   +12 more
doaj   +1 more source

The use of stained cytologic direct smears for ALK gene rearrangement analysis of lung adenocarcinoma [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100150/1/cncy21286 ...
Betz, Bryan L., Dixon, Catherine A., Knoepp, Stewart M., Roh, Michael H., Weigelin, Helmut C.   +4 more
core   +1 more source

MET nucleotide variations and amplification in advanced ovarian cancer: characteristics and outcomes with c-Met inhibitors. [PDF]

, 2013
PurposeMET alterations including amplifications and nucleotide variations have been associated with resistance to therapy and aggressive clinical behavior.Experimental designThe medical records of patients presenting to the University of Texas MD ...
De Melo Galgiato, Debora, Falchook, Gerald S, Fu, Siqing, Hess, Kenneth, Hong, David S, Jardim, Denis L Fontes, Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Tang, Chad, Tsimberidou, Apostolia M, Westin, Shannon N, Wheler, Jennifer J, Zinner, Ralph G   +13 more
core   +7 more sources

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumor with sarcomatous morphology and distant metastases: An unusual histomorphology and behavior

Indian Journal of Pathology and Microbiology, 2015
Inflammatory myofibroblastic tumor (IMT), an intermediate-grade neoplasm of myofibroblastic/fibroblastic differentiation, occurs commonly in children and young adults.
Bhawna Sethi, Trupti Pai, Abhishek Allam, Sridhar Epari   +3 more
doaj   +1 more source