Results 81 to 90 of about 21,294 (218)

First-in-human, open-label dose-escalation and dose-expansion study of the safety, pharmacokinetics, and antitumor effects of an oral ALK inhibitor ASP3026 in patients with advanced solid tumors [PDF]

, 2016
Background ASP3026 is a second-generation anaplastic lymphoma kinase (ALK) inhibitor that has potent in vitro activity against crizotinib-resistant ALK-positive tumors.
Anthony Tolcher, Erkut Bahceci, Geoffrey Yuen, Howard A. Ball, Jung Wook Park, Michael L. Maitland, Patricia LoRusso, Sai-Hong Ignatius Ou, Tianhong Li   +8 more
core   +3 more sources

Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer

Case Reports in Oncology, 2018
Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug.
Sachi Okawa, Takuo Shibayama, Atsushi Shimonishi, Jun Nishimura, Taichi Ozeki, Kenji Takada, Hiroe Kayatani, Daisuke Minami, Ken Sato, Keiichi Fujiwara, Toshiro Yonei, Toshio Sato, Manabu Suno   +12 more
doaj   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones

The Journal of Dermatology, EarlyView.
ABSTRACT Mycosis fungoides (MF) is a unique type of lymphoma with an excellent prognosis presenting with a wide variety of clinical and histological findings. Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity.
Ryoma Honda, Toshihisa Hamada, Makoto Sugaya   +2 more
wiley   +1 more source

A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer. [PDF]

, 2012
Metastatic non-small cell lung cancer (NSCLC) carries a dismal prognosis. Clinical evidence suggests the existence of an intermediate, or oligometastatic, state when metastases are limited in number and/or location.
Niibe, Yuzuru, Patel, Pretesh R, Salama, Joseph K, Urbanic, James J, Yoo, David S   +4 more
core   +3 more sources

Small cell lung cancer with EML4-ALK fusion: report of a case responding to ALK TKI and literature review

Journal of Cancer Research and Clinical Oncology
Purpose With the continuous development and progress of next-generation gene sequencing technology, many types of anaplastic lymphoma kinase (ALK) rearrangement have been discovered.
Mingyue Wang, Hongzhi Liu, Ruixin Zhang, Runyu Li, Xiaoyu Qin, Fangling Ning, Lijun Tian   +6 more
doaj   +1 more source

ALK-Positive Squamous Cell Carcinoma Dramatically Responded to Alectinib

Case Reports in Oncological Medicine, 2018
Anaplastic lymphoma kinase (ALK) rearrangement is usually observed in patients with adenocarcinoma. Herein, we report a case of squamous cell carcinoma (SCC) with ALK rearrangement treated with alectinib.
Ray Sagawa, Takehiko Ohba, Eisaku Ito, Susumu Isogai   +3 more
doaj   +1 more source

ALK-rearranged renal cell carcinomas in Polish population

Pathology - Research and Practice, 2019
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, the activation of which is considered an important event in the pathogenesis of several neoplasms and a predictive factor for the targeted therapy with ALK inhibitors. Thus far, ALK rearrangements have been identified in 22 renal cell carcinomas in both pediatric and adult patients.
Adam, Gorczynski, Piotr, Czapiewski, Aleksandra, Korwat, Lukasz, Budynko, Monika, Prelowska, Krzysztof, Okon, Wojciech, Biernat   +6 more
openaire   +4 more sources

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Nichtkleinzellige Lungenkarzinome: Subklassifikation und prädiktive molekulare Markeruntersuchungen in der Zytologie [PDF]

, 2018
Zusammenfassung: In der Lungenkarzinomdiagnostik haben sich die Anforderungen an die Zytologie in den letzen Jahren deutlich verändert. Eine exakte Subtypisierung nichtkleinzelliger Lungenkarzinome (NSCLC) in Adeno- und Plattenepithelkarzinome ...
Bihl, M.P., Bubendorf, L., Savic, S.
core