Results 171 to 180 of about 232,220 (312)

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Pseudo-Natural Products Inspired by Aryloctahydroindole Alkaloids. [PDF]

ChemMedChem
Greiner LC, Bernal FA, Thavam S, Brachthäuser M, Sievers S, Ziegler S, Waldmann H.   +6 more
europepmc   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Biochemical and Genetic Characterization of Ergot Alkaloid Biosynthesis in Aspergillus aspearensis. [PDF]

Toxins (Basel)
Fuss JL, Panaccione DG.
europepmc   +1 more source

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Oxygen Attachment Dissociation of Protonated Reserpine and Its Analogs. [PDF]

Rapid Commun Mass Spectrom
Li JG, Bowen CJ, Chan B, Stewart AWE, Takahashi H, O'Hair RAJ.   +5 more
europepmc   +1 more source

Morpho‐Anatomical and HPTLC Investigations of Lysimachia nummularia L. (Primulaceae) Grown in Switzerland

Microscopy Research and Technique, EarlyView.
This research provides a complete morphoanatomical description of Lysimachia nummularia, as well as a HPTLC profile. Standard techniques of light and scanning electron microscopies, as well as standard techniques of HPTLC, were used. ABSTRACT Primulaceae are distributed all over the world, encompassing around 2590 species.
Carolina Sabedotti, João Vitor da Costa Batista, Bettina Leonhard, Konrad Urech, Mahsa Ahmadinezhad, Jakob Maier, Stephan Baumgartner, Fabio Boylan, Carla Holandino, Jane Manfron   +9 more
wiley   +1 more source

Arkansas Animal Science Department Report 2015 [PDF]

, 2015
Apple, Jason, Beck, Paul, Kegley, Beth, Rosenkrans, Charles, Jr.   +3 more
core   +2 more sources

Chiral N-acyliminium ions as new tools in the asymmetric synthesis of CNS-active compounds [PDF]

, 1994
Beutler, Comins, Gray, Hellmann, Irie, K.Th. Wanner, Kiguchi, Wanner, Wanner, Wong   +9 more
core   +1 more source

Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding. [PDF]

Sci Rep
Rady MR, Mabrouk DM, Ibrahim MM.
europepmc   +1 more source