Results 71 to 80 of about 57,411 (307)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Note on the Hyper-Wiener Index [PDF]

Journal of the Serbian Chemical Society, 2003
The hyper-Wiener index WW of a chemical tree T is defined as the sum of the products n1n2, over all pairs u, u of vertices of T, where n1 and n2 are the number of vertices of T, lying on the two sides of the path which connects u and u.
IVAN GUTMAN, BORIS FURTULA, JASMINA BELIC   +2 more
doaj  

Avanços metodológicos na determinação do consumo de ruminantes em pastejo Advances in methods for determining animal intake on pasture

Revista Brasileira de Zootecnia, 2007
Avanços metodológicos são, usualmente, conseqüência direta de avanços conceituais e tecnológicos. No caso da estimativa do consumo em pastejo, os recentes avanços conceituais relativos ao processo de busca e apreensão da forragem pelo ruminante ...
Paulo César de Faccio Carvalho, Gilberto Vilmar Kozloski, Henrique Mendonça Nunes Ribeiro Filho, Mônica Vizzotto Reffatti, Teresa Cristina Moraes Genro, Valéria Pacheco Batista Euclides   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Description of complexation thermodynamic parameters for alkanes and polyaromatic hydrocarbons in the framework of semiempirical methods

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
The paper presents a comparative analysis of quantum chemical semiempirical methods for calculation of the binding thermodynamic parameters for CnH2n+2 alkanes (n=6–14) and polyaromatic hydrocarbons of the coronene series as model structures of the ...
E.S. Kartashynska
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

(Table 2b) Distribution of alkanes in bottom sediments from the Baltic Sea

, 1981
(Table 2b) Distribution of alkanes in bottom sediments from the Baltic ...
Alexandra N Belyaeva (6967250), Nadezhda V Bobyleva (7964087), Bobyleva, Nadezhda V, Belyaeva, Alexandra N   +3 more
core   +1 more source

Wiener-type indices and internal molecular energy [PDF]

Journal of the Serbian Chemical Society, 2003
In earlier studies it was established that internal molecular energies (Eint) of alkanes can be reproduced, in an approximate yet reliable manner, by means of a molecular-graph-based structure-descriptor U.
BORIS FURTULA, IGOR G. ZENKEVICH, DUSICA VIDOVIC, IVAN GUTMAN   +3 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

(Table 1) Total yield of C4-C7 alkanes from DSDP samples

, 1975
(Table 1) Total yield of C4-C7 alkanes from DSDP ...
Hunt, John M, John M Hunt (6982064)
core   +1 more source