Results 51 to 60 of about 32,609 (264)

The potential use of n-alkanes, long-chain alcohols and long-chain fatty acids as diet composition markers: indoor validation with sheep and herbage species from the rangeland of Inner Mongolia of China

Animal, 2012
To investigate the potential use of n-alkanes (alkanes), long-chain alcohols (alcohols) and long-chain fatty acids (acids) for estimating the diet composition of sheep, in a feeding trial.
L.J. Lin, X.Y. Zhu, C. Jiang, H.L. Luo, H. Wang, Y.J. Zhang, F.Z. Hong   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Vapour-liquid equilibrium of the OPLS, optimized potentials for liquid simulations, model for binary systems of alkanes and alkanes + alcohols [PDF]

Journal of the Serbian Chemical Society, 2005
The NpT - Gibbs ensemble Monte Carlo computer simulation method was applied to predict the vapour-liquid equilibrium (VLE) behavior of the binary systems ethane + pentane at 277.55 K and 310.95 K, ethane + hexane at 298.15 K, propane + methanol at 313.15
Šerbanović Slobodan P., Mijajlović Milan LJ., Radović Ivona R., Đorđević Bojan D., Kijevčanin Mirjana LJ., Đorđević Emila M., Tasić Aleksandar Ž.   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Note on the Hyper-Wiener Index [PDF]

Journal of the Serbian Chemical Society, 2003
The hyper-Wiener index WW of a chemical tree T is defined as the sum of the products n1n2, over all pairs u, u of vertices of T, where n1 and n2 are the number of vertices of T, lying on the two sides of the path which connects u and u.
IVAN GUTMAN, BORIS FURTULA, JASMINA BELIC   +2 more
doaj  

Avanços metodológicos na determinação do consumo de ruminantes em pastejo Advances in methods for determining animal intake on pasture

Revista Brasileira de Zootecnia, 2007
Avanços metodológicos são, usualmente, conseqüência direta de avanços conceituais e tecnológicos. No caso da estimativa do consumo em pastejo, os recentes avanços conceituais relativos ao processo de busca e apreensão da forragem pelo ruminante ...
Paulo César de Faccio Carvalho, Gilberto Vilmar Kozloski, Henrique Mendonça Nunes Ribeiro Filho, Mônica Vizzotto Reffatti, Teresa Cristina Moraes Genro, Valéria Pacheco Batista Euclides   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Description of complexation thermodynamic parameters for alkanes and polyaromatic hydrocarbons in the framework of semiempirical methods

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
The paper presents a comparative analysis of quantum chemical semiempirical methods for calculation of the binding thermodynamic parameters for CnH2n+2 alkanes (n=6–14) and polyaromatic hydrocarbons of the coronene series as model structures of the ...
E.S. Kartashynska
doaj   +1 more source