Results 221 to 230 of about 10,203 (251)

Complete genome sequences of nine isolates from microplastics in the Bow River, Calgary, Canada. [PDF]

Microbiol Resour Announc
Goff KL, Suresh S, Stadfeld JM, Bhatnagar S.   +3 more
europepmc   +1 more source

A comprehensive analysis of supermere, exomere, and extracellular vesicle isolation and cargo in colorectal cancer. [PDF]

Cell Rep
Tutanov OS, Massick C, Ramirez M, Higginbotham JN, Jimenez L, Castleberry M, Cao Z, John E, Hamilton MS, Zhang Q, Jeppesen DK, Michell DL, Glass SE, Patel P, Rose KL, Krystofiak E, Chen HC, Sheng Q, Liu Q, Patton JG, Weaver AM, Franklin JL, Vickers KC, Coffey RJ.   +23 more
europepmc   +1 more source

Substrate specificities of bacterial and human AlkB proteins [PDF]

Nucleic Acids Research, 2004
Methylating agents introduce cytotoxic 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) residues into nucleic acids, and it was recently demonstrated that the Escherichia coli AlkB protein and two human homologues, hABH2 and hABH3, can remove these lesions from DNA by oxidative demethylation. Moreover, AlkB and hABH3 were also found to remove 1-meA
Pål Ø Falnes, Magnar Bjørås
exaly   +3 more sources

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Structure and Function of Alkane Monooxygenase (AlkB)

Accounts of Chemical Research, 2023
Every year, perhaps as much as 800 million tons of hydrocarbons enters the environment; alkanes make up a large percentage of it. Most are transformed by organisms that utilize these molecules as sources of energy and carbon. Both aerobic and anaerobic alkane transformation chemistries exist, capitalizing on the presence of alkanes in both oxic and ...
John T. Groves, Liang Feng, Rachel Narehood Austin   +2 more
openaire   +2 more sources

DNA repair by bacterial AlkB proteins

Research in Microbiology, 2003
The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins.
Pål Ø, Falnes, Torbjørn, Rognes
openaire   +2 more sources

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

Nature, 2002
The bacterial AlkB protein is known to be involved in cellular recovery from alkylation damage; however, the function of this protein remains unknown. AlkB homologues have been identified in several organisms, including humans, and a recent sequence alignment study has suggested that these proteins may belong to a superfamily of 2-oxoglutarate ...
Pål Ø Falnes
exaly   +3 more sources

AlkB demethylases flip out in different ways

DNA Repair, 2008
Aberrant methylations in DNA are repaired by base excision repair (BER) and direct repair by a methyltransferase or by an oxidative demethylase of the AlkB type. Yang et al. [Nature 452 (2008) 961-966] have now solved the crystal structure of AlkB and human AlkB homolog 2 (hABH2) in complex with DNA using an ingenious crosslinking strategy to stabilize
Ottar, Sundheim, Vivi A, Talstad, Cathrine Broberg, Vågbø, Geir, Slupphaug, Hans E, Krokan   +4 more
openaire   +2 more sources