Results 71 to 80 of about 6,174 (170)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

A novel strategy for partial purification of alkane hydroxylase from P. chrysogenum SNP5 through reconstituting its native membrane into liposome

Scientific Reports
Integral proteins or enzymes are still challenging to purify into their native state because of their need for an amphipathic environment and cofactors.
Satyapriy Das, Sangeeta Negi
doaj   +1 more source

Diversity of Metabolically Active Bacteria in Water-Flooded High-Temperature Heavy Oil Reservoir

Frontiers in Microbiology, 2017
The goal of this work was to study the overall genomic diversity of microorganisms of the Dagang high-temperature oilfield (PRC) and to characterize the metabolically active fraction of these populations.
Tamara N. Nazina, Natalya M. Shestakova, Ekaterina M. Semenova, Alena V. Korshunova, Nadezda K. Kostrukova, Tatiana P. Tourova, Liu Min, Qingxian Feng, Andrey B. Poltaraus   +8 more
doaj   +1 more source

Understanding plant-microbe interactions for phytoremediation of petroleum-polluted soil.

PLoS ONE, 2011
Plant-microbe interactions are considered to be important processes determining the efficiency of phytoremediation of petroleum pollution, however relatively little is known about how these interactions are influenced by petroleum pollution.
Ming Nie, Ming Nie, Yijing Wang, Jiayi Yu, Ming Xiao, Lifen Jiang, Ji Yang, Changming Fang, Jiakuan Chen, Bo Li   +9 more
doaj   +1 more source

Identity and mechanisms of alkane-oxidizing metalloenzymes from deep-sea hydrothermal vents

Frontiers in Microbiology, 2013
Six aerobic alkanotrophs (organism that can metabolize alkanes as their sole carbon source) isolated from deep-sea hydrothermal vents were characterized using the radical clock substrate norcarane to determine the metalloenzyme and reaction mechanism ...
Rachel Narehood Austin, Erin M. Bertrand, Erin M. Bertrand, John T Groves, Costantino eVetriani, Ramaydalis eKeddis   +5 more
doaj   +1 more source

NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli

Nature Communications, 2019
Bacterial tRNA is modified by thiolation of nucleosides. Here the authors identify 2-methylthiocytidine in bacterial tRNA using nucleic acid isotope labeling coupled mass spectrometry.
Valentin F. Reichle, Dimitar P. Petrov, Verena Weber, Kirsten Jung, Stefanie Kellner   +4 more
doaj   +1 more source

Degradation of diesel fuel by Pseudomonas aeruginosa B031 with expression of the alkB gene in a column bioreactor

Journal of Degraded and Mining Lands Management
Diesel fuel pollutants contain toxic hydrocarbons dominated by aliphatic and aromatic hydrocarbons. Hydrocarbon pollutants can be degraded in an environmentally friendly manner through bioremediation using hydrocarbonoclastic bacteria, i.e., Pseudomonas ...
Pieter Jhon Joshua Daris, Wahyu Wilopo, Wayan Warmada, Endah Retnaningrum   +3 more
doaj   +1 more source

Effects of changes in intracellular iron pool on AlkB-dependent and AlkB-independent mechanisms protecting E.coli cells against mutagenic action of alkylating agent

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2015
An Escherichia coli hemH mutant accumulates protoporphyrin IX, causing photosensitivity of cells to visible light. Here, we have shown that intracellular free iron in hemH mutants is double that observed in hemH(+) strain. The aim of this study was to recognize the influence of this increased free iron concentration on AlkB-directed repair of alkylated
Anna, Sikora, Agnieszka M, Maciejewska, Jarosław, Poznański, Tomasz, Pilżys, Michał, Marcinkowski, Małgorzata, Dylewska, Jan, Piwowarski, Wioletta, Jakubczak, Katarzyna, Pawlak, Elżbieta, Grzesiuk   +9 more
openaire   +3 more sources

The biological function of demethylase ALKBH1 and its role in human diseases

Heliyon
AlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong, Zhengyang Xu, Ning Ding, Yanting Wang, Wenwen Chen   +4 more
doaj   +1 more source

ALKBH1: emerging biomarker and therapeutic target for cancer treatment

Discover Oncology
As neoplastic cells proliferate, disseminate, and infiltrate, they undergo substantial alterations in their epigenetic configuration. Among the pivotal enzymes implicated in this phenomenon is the AlkB family of demethylases, notably AlkB homolog 1 ...
Ming Zhu Xiao, Jin Yin Fu, Le Tao Bo, Yi Dong Li, Zhong Wei Lin, Zhe Sheng Chen   +5 more
doaj   +1 more source