Results 1 to 10 of about 98 (85)

The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma

Frontiers in Oncology, 2022
The AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases works by removing alkyl substituents from alkylation-damaged nucleic acid bases through oxidative dealkylation, subsequently affecting tumor progression and patient prognosis. However,
Songshan Feng, Zhijie Xu, Zhijie Xu, Zhijie Xu, Jinwu Peng, Jinwu Peng, Jinwu Peng, Mingyu Zhang   +7 more
doaj   +3 more sources

Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, Kunjin Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, Ronald Sederoff, Yun Li   +10 more
doaj   +3 more sources

Structural Analysis of the AlkB Family in Poultry

Animals
The objective of this study was to identify the AlkB family genes in poultry using bioinformatics, and to explore their molecular characteristics, evolutionary relationships, and expression patterns to clarify their potential functions in poultry.
Yuling Niu, Kan Li, Xuerong You, Yutao Wu, Xue Du, Ayong Zhao, Zhijun Wang   +6 more
doaj   +3 more sources

Genome-wide identification and characterization of ALKB homolog gene family in wheat (Triticum aestivum L.)

Frontiers in Plant Science
IntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang, Tianye Zhang, Zechi Wu, Lei Yu, Pingan Liao, Jian Yang, Bingjian Sun   +6 more
doaj   +3 more sources

The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma [PDF]

PeerJ, 2021
Background Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known.
Bi Peng, Yuanliang Yan, Zhijie Xu
doaj   +2 more sources

Genome-wide sequence identification and expression analysis of N6-methyladenosine demethylase in sugar beet (Beta vulgaris L.) under salt stress [PDF]

PeerJ, 2022
In eukaryotes, N6-methyladenosine (m6A) is the most abundant and highly conserved RNA modification. In vivo, m6A demethylase dynamically regulates the m6A level by removing the m6A marker where it plays an important role in plant growth, development and ...
Jie Cui, Junli Liu, Junliang Li, Dayou Cheng, Cuihong Dai   +4 more
doaj   +2 more sources

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis

Frontiers in Cell and Developmental Biology, 2021
The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu, Yuanliang Yan, Yuan Cai, Bi Peng, Juanni Li, Jinzhou Huang, Zhijie Xu, Zhijie Xu, Jianhua Zhou   +8 more
doaj   +1 more source

The role of demethylase AlkB homologs in cancer

Frontiers in Oncology, 2023
The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
doaj   +1 more source

An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB)

Frontiers in Microbiology, 2022
Alkane-oxidizing enzymes play an important role in the global carbon cycle. Alkane monooxygenase (AlkB) oxidizes most of the medium-chain length alkanes in the environment. The first AlkB identified was from P.
Shoshana C. Williams, Rachel Narehood Austin   +1 more
doaj   +1 more source

Kinetic Studies on the 2-Oxoglutarate/Fe(II)-Dependent Nucleic Acid Modifying Enzymes from the AlkB and TET Families

DNA, 2023
Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Zhiyuan Peng, Jian Ma, Christo Z. Christov, Tatyana Karabencheva-Christova, Nicolai Lehnert, Deyu Li   +5 more
doaj   +1 more source