Results 1 to 10 of about 559 (103)

Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas

Frontiers in Immunology, 2022
BackgroundAlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase associated with the development, growth, and progression of multiple cancer types.
Lei Han, Jianning Zhang, Li Shenghui
exaly   +3 more sources

RNA demethylase ALKBH5 suppresses tumorigenesis via inhibiting proliferation and invasion and promoting CD8+ T cell infiltration in colorectal cancer

Translational Oncology, 2023
Summary: Background: ALKBH5 belongs to the ALKB family consists of a Fe (II) and a-ketoglutarate-dependent dioxygenase. ALKBH5 directly catalyzes the oxidative demethylation of m6A-methylated adenosine.
Jing Ge, Tao Yang
exaly   +3 more sources

ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction

Journal of Advanced Research
Introduction: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A “eraser”, is responsible for decreased m6A modification.
Xiang Wei, Rifeng Gao, Aijun Sun
exaly   +3 more sources

The involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer

Cancer Biology & Therapy, 2023
Infection with high-risk human papillomavirus (HPV), for example, with types 16 and 18, is closely associated with cervical cancer development, which continues to threaten women’s health globally.
Suzhen Wu, Lili Liu, Huanying Xu, Qiaoling Zhu, Minhua Tan   +4 more
doaj   +1 more source

K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis

Nature Communications, 2023
N6-methyladenosine (m6A) modification plays important roles in bioprocesses and diseases. AlkB homolog 5 (ALKBH5) is one of two m6A demethylases.
Xiao-Lan Zhang, Xin-Hui Chen, Binwu Xu, Min Chen, Song Zhu, Nan Meng, Ji-Zhong Wang, Huifang Zhu, De Chen, Jin-Bao Liu, Guang-Rong Yan   +10 more
doaj   +1 more source

ALKBH5 inhibits TNF-α-induced apoptosis of HUVECs through Bcl-2 pathway

Open Medicine, 2022
The dysfunction and apoptosis of vascular endothelial cells are the initiating links in the formation of atherosclerosis. N6-methyladenosine (m6A) is an extremely extensive RNA methylation modification and its abnormality leads to the occurrence of ...
Zhang Xiaoshan, Deng ShiBing, Peng Yang, Wei Han, Tian Zhiming   +4 more
doaj   +1 more source

ALKBH5 involves in osteosarcoma tumor progression by mediating Notch signaling

Precision Medical Sciences, 2023
ALKBH5 is the major demethylase of ribonuclease m6A and exerts these multiple biological functions in cancer. In this study, we mainly explore the use of ALKBH5 in the development and progression of osteosarcoma and elucidate the potential molecular ...
Dagui Chen, Jiebing Zhao, Hao Tian, Fusheng Shang, Jianjun Feng   +4 more
doaj   +1 more source

ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N  6 -methyladenosine methylation

Nature Communications, 2023
N 6 -methyladenosine (m6A) maintains maternal RNA stability in oocytes. One regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism. However, the specific role of ALKBH5 in oocyte maturation remains elusive.
Long Bai, Yu Xiang, Minyue Tang, Shuangying Liu, Qingqing Chen, Qichao Chen, Min Zhang, Shan Wan, Yimiao Sang, Qingfang Li, Sisi Wang, Zhekun Li, Yang Song, Xiaoling Hu, Luna Mao, Guofang Feng, Long Cui, Yinghui Ye, Yimin Zhu   +18 more
doaj   +1 more source

RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner

Clinical and Translational Medicine, 2023
Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) is a well‐described m6A demethylase in previous enzyme assays, we aimed to investigate the role of
Dingcheng Shen, Jinxin Lin, Yumo Xie, Zhuokai Zhuang, Gaopo Xu, Shaoyong Peng, Guannan Tang, Liangliang Bai, Mingxuan Zhu, Yu Zhang, Ziying Huang, Puning Wang, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Xiaolin Wang, Huichuan Yu   +16 more
doaj   +1 more source

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation

Clinical and Translational Medicine, 2022
Background As the most widespread mRNAs modification, N6‐methyladenosine (m6A) is dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is a major demethylase, and plays vital roles in the progression of cancers.
Zhen Zhang, Ling Wang, Long Zhao, Quan Wang, Changjiang Yang, Mengmeng Zhang, Bo Wang, Kewei Jiang, Yingjiang Ye, Shan Wang, Zhanlong Shen   +10 more
doaj   +1 more source