Results 11 to 20 of about 559 (103)

ALKBH5-mediated CHAC1 depletion promotes malignant progression and decreases cisplatin-induced oxidative stress in gastric cancer

Cancer Cell International, 2023
The m6a demethyltransferase ALKBH5 dynamically modulates gene expression and intracellular metabolic molecules by modifying RNA m6a in cancer cells. However, ALKBH5’s function in gastric cancer (GC) has remained controversial.
Chunting Chen, Ertao Zhai, Yinan Liu, Yan Qian, Risheng Zhao, Yan Ma, Jianqiu Liu, Zhixin Huang, Jianhui Chen, Shirong Cai   +9 more
doaj   +1 more source

Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A

Clinical and Translational Medicine, 2021
Background Post‐ischemic angiogenesis is critical for blood flow recovery and ischemic tissue repair. N6‐methyladenosine (m6A) plays essential roles in numerous biological processes.
Yongchao Zhao, Jingjing Hu, Xiaolei Sun, Kun Yang, Lebing Yang, Lingqiu Kong, Beijian Zhang, Fuhai Li, Chaofu Li, Bei Shi, Kai Hu, Aijun Sun, Junbo Ge   +12 more
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A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis

BMC Cancer, 2021
Background Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported to involve in multiple cancers including Hepatocellular Carcinoma ...
Siming Qu, Li Jin, Hanfei Huang, Jie Lin, Weiwu Gao, Zhong Zeng   +5 more
doaj   +1 more source

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Molecular Cancer, 2020
Background N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis.
Xingya Guo, Kai Li, Weiliang Jiang, Yangyang Hu, Wenqin Xiao, Yinshi Huang, Yun Feng, Qin Pan, Rong Wan   +8 more
doaj   +1 more source

m6A demethylase ALKBH5 restrains migration and invasion and Wnt signaling pathway activity of gastric cancer cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of RNA demethylase ALKBH5 on migration and invasion of gastric cancer (GC) cells and its potential mechanism. Methods Cancer Genome Atlas (TCGA) was employed to determine the correlation of ALKBH5 expression variations
SHEN Liting, LI Jinyang, LI Xianfeng, CHE Linrong, LIU Kewei, LIU Qin, WANG Bin, QIN Zhongyi, CHEN Dongfeng   +8 more
doaj   +1 more source

N6-methyladenosine-regulated ADIRF impairs lung adenocarcinoma metastasis and serves as a potential prognostic biomarker

Cancer Biology & Therapy, 2023
Aberrant expression of adipogenic regulatory factors (ADIRF) in tumor cells is critical for tumor growth and metastasis. N6-methyladenosine (m6A) modifications have an important role in a variety of biological activities.
Yin Teng, Xiaohan Zhao, Yang Xi, Ninghua Fu   +3 more
doaj   +1 more source

m6A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal3

iScience, 2023
Summary: The clinical application of anthracyclines such as doxorubicin (DOX) is limited due to their cardiotoxicity. N6-methyladenosine (m6A) plays an essential role in numerous biological processes.
Ri-Feng Gao, Kun Yang, Ya-Nan Qu, Xiang Wei, Jia-Ran Shi, Chun-Yu Lv, Yong-Chao Zhao, Xiao-Lei Sun, Ying-Jia Xu, Yi-Qing Yang   +9 more
doaj   +1 more source

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis

Frontiers in Physiology, 2022
Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase
Cheng Tian, Jihua Chai, Weidong Liu, Xinye Zhang, Yashu Li, Huanyan Zuo, Guohua Yuan, Haojian Zhang, Haojian Zhang, Huan Liu, Huan Liu, Zhi Chen, Zhi Chen   +12 more
doaj   +1 more source

N⁶-methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes

Acta Biochimica et Biophysica Sinica, 2021
Previous studies have reported that the N6-methyladenosine demethylase ALKBH5 can regulate adipogenesis in humans. However, its function in birds remains unclear. In this study we aimed to explore the expression and function of the ALKBH5 gene in chicken
Zhang Qi, Cheng Bohan, Jiang Haixu, Zhang Huili, Li Hui   +4 more
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ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC). ALKBH5 has recently been shown to be one of the RNA N6-methyladenosine (m6A) demethyltransferases associated with various cancers, but its
Sipei Nie, Lin Zhang, Jinhui Liu, Yicong Wan, Yi Jiang, Jing Yang, Rui Sun, Xiaolling Ma, Guodong Sun, Huangyang Meng, Mengting Xu, Wenjun Cheng   +11 more
doaj   +1 more source