Results 31 to 40 of about 559 (103)
Cellular & Molecular Biology Letters, 2022 Background RNA N 6-methyladenosine (m6A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulates spermatogenesis and androgen synthesis in an m6A-dependent manner. However, it is unclear whether ALKBH5 plays a role
Zhonglin Cai +9 more
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Advanced Science, EarlyView.This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng +13 more
wiley +1 more source
Mechanism of ALKBH5 mediated m6A regulation of Galectin-9 in the invasion, migration, and proliferation of endometrial stromal cell [PDF]
Yixue xinzhi zazhiObjective To investigate the potential role of ALKBH5-mediated m6A modification of Galectin-9 in the invasion, migration, and proliferation of endometrial stromal cells (ESCs) in endometriosis.Methods A total of 20 normal endometrial (NC) specimens and ...
WANG Fang +3 more
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HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5
Pharmacological Research, 2023 Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC). N6-methyladenosine (m6A) modification is implicated in carcinogenesis and tumor progression.
Fu-Chun Huo +8 more
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Advanced Science, EarlyView.Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan +13 more
wiley +1 more source
Scientific ReportsThe significance of ALKBH5 in erasing mRNA methylation in mRNA biogenesis, decay, and translation control has emerged as a prominent research focus. Additionally, ALKBH5 is associated with the development of numerous human cancers.
Yong Zhuang +3 more
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Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress
Advanced Science, EarlyView.Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang +18 more
wiley +1 more source
The role of the ALKBH5 RNA demethylase in invasive breast cancer
Discover OncologyBackground N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase.
Corinne L. Woodcock +15 more
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Brain Research BulletinThis study aimed to investigate the role of the m6A demethylase ALKBH5 in RIPostC against CI/R injury and its underlying regulatory mechanism. A rat model of CI/R was established using the MCAO method.
Aimei Wang +7 more
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