Results 11 to 20 of about 128 (100)

Genome-Wide Identification and Characterization of the AlkB Gene Family in Sweet Orange (Citrus sinensis)

Current Issues in Molecular Biology, 2022
Sweet orange (Citrus sinensis) is a sub-tropical fruit crop with important economic value that is popular worldwide; however, various pathogens significantly affect citrus cultivation and distribution.
Aijun Huang, Ying Wang, Peipei Gu, Zhixun Yang, Junna Han, Long Yi   +5 more
doaj   +3 more sources

Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family

Current Issues in Molecular Biology
Alkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva, Nikita A. Kuznetsov   +1 more
doaj   +3 more sources

Genome-Wide Identification of the Soybean AlkB Homologue Gene Family and Functional Characterization of GmALKBH10Bs as RNA m⁶A Demethylases and Expression Patterns under Abiotic Stress

Plants
Soybean (Glycine max (L.) Merr) is one of the most important crops worldwide, but its yield is vulnerable to abiotic stresses. In Arabidopsis, the AlkB homologue (ALKBH) family genes plays a crucial role in plant development and stress response. However,
Jie Zhao, Tengfeng Yang, Peng Liu, Huijie Liu, Hui Zhang, Sichao Guo, Xiaoye Liu, Xiaoguang Chen, Mingjia Chen   +8 more
doaj   +3 more sources

Expression and molecular profiles of the AlkB family in ovarian serous carcinoma

Aging, 2021
AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases plays essential roles in development of ovarian serous carcinoma (OV). However, the molecular profiles of AlkB family in OV have not been clarified. The results indicated that the expression of ALKBH1/3/5/8 and FTO was lower in OV patients while ALKBH2/4/6/7 expression was higher.
Cai, Yuan, Wu, Geting, Peng, Bi, Li, Juanni, Zeng, Shuangshuang, Yan, Yuanliang, Xu, Zhijie   +6 more
openaire   +2 more sources

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

eLife, 2021
Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes.
Braulio Bonilla, Alexander J Brown, Sarah R Hengel, Kyle S Rapchak, Debra Mitchell, Catherine A Pressimone, Adeola A Fagunloye, Thong T Luong, Reagan A Russell, Rudri K Vyas, Tony M Mertz, Hani S Zaher, Nima Mosammaparast, Ewa P Malc, Piotr A Mieczkowski, Steven A Roberts, Kara A Bernstein   +16 more
doaj   +1 more source

ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis

Molecular Therapy: Nucleic Acids, 2021
N6-methyladenosine (m6A) is the most commonly occurring internal RNA modification to be found in eukaryotic mRNA and serves an important role in various physiological events.
Hao Yu, Xiao Yang, Jinyuan Tang, Shuhui Si, Zijian Zhou, Jiancheng Lu, Jie Han, Baorui Yuan, Qikai Wu, Qiang Lu, Haiwei Yang   +10 more
doaj   +1 more source

Dataset for Spectroscopic, Structural and Dynamic Analysis of Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3

Data, 2023
Fe(II)/2OG-dependent dioxygenases of the AlkB family catalyze a direct removal of alkylated damages in the course of DNA and RNA repair. A human homolog of the E. coli AlkB ALKBH3 protein is able to hydroxylate N1-methyladenine, N3-methylcytosine, and N1-
Lyubov Yu. Kanazhevskaya, Alexey A. Gorbunov, Polina V. Zhdanova, Vladimir V. Koval   +3 more
doaj   +1 more source

Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. [PDF]

PLoS ONE, 2010
Escherichia coli AlkB is a 2-oxoglutarate- and iron-dependent dioxygenase that reverses alkylated DNA damage by oxidative demethylation. Mouse AlkB homolog 1 (Alkbh1) is one of eight members of the newly discovered family of mammalian dioxygenases.In the
Line M Nordstrand, Jessica Svärd, Elisabeth Larsen, Anja Nilsen, Rune Ougland, Kari Furu, Guro F Lien, Torbjørn Rognes, Satoshi H Namekawa, Jeannie T Lee, Arne Klungland   +10 more
doaj   +1 more source

Sequence Dependent Repair of 1,N⁶-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB

Molecules, 2021
Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair.
Rui Qi, Ke Bian, Fangyi Chen, Qi Tang, Xianhao Zhou, Deyu Li   +5 more
doaj   +1 more source

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

BMC Genomics, 2003
Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz, Bhagwat Ashok S, Kurowski Michal A, Bujnicki Janusz M   +3 more
doaj   +1 more source