The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qingsan Zhu, Zhu Qingsan
exaly +3 more sources
An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB)
Frontiers in Microbiology, 2022 Alkane-oxidizing enzymes play an important role in the global carbon cycle. Alkane monooxygenase (AlkB) oxidizes most of the medium-chain length alkanes in the environment. The first AlkB identified was from P.
Rachel Narehood Austin
exaly +3 more sources
The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma [PDF]
PeerJ, 2021 Background Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known.
Bi Peng, Yuanliang Yan, Zhijie Xu
doaj +2 more sources
The Use of a Combination of alkB Primers to Better Characterize the Distribution of Alkane-Degrading Bacteria. [PDF]
PLoS ONE, 2013 The alkane monooxygenase AlkB, which is encoded by the alkB gene, is a key enzyme involved in bacterial alkane degradation. To study the alkB gene within bacterial communities, researchers need to be aware of the variations in alkB nucleotide sequences ...
Diogo Jurelevicius +4 more
doaj +1 more source
Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. [PDF]
PLoS ONE, 2010 BACKGROUND: In Escherichia coli, cytotoxic DNA methyl lesions on the N1 position of purines and N3 position of pyrimidines are primarily repaired by the 2-oxoglutarate (2-OG) iron(II) dependent dioxygenase, AlkB.
Paul J Holland, Thomas Hollis
doaj +1 more source
The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma
Frontiers in Oncology, 2022 The AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases works by removing alkyl substituents from alkylation-damaged nucleic acid bases through oxidative dealkylation, subsequently affecting tumor progression and patient prognosis. However,
Songshan Feng +7 more
doaj +1 more source
A novel alkane monooxygenase (alkB) clade revealed by massive genomic survey and its dissemination association with IS elements [PDF]
PeerJ, 2022 Background Alkanes are important components of fossil energy, such as crude oil. The alkane monooxygenase encoded by alkB gene performs the initial step of alkane degradation under aerobic conditions.
Shaojing Wang +4 more
doaj +2 more sources
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini
Cell Discovery, 2021 High-throughput sequencing reveals the complex landscape of small noncoding RNAs (sRNAs). However, it is limited by requiring 5′-monophosphate and 3′-hydroxyl in RNAs for adapter ligation and hindered by methylated nucleosides that interfere with reverse
Heming Wang +9 more
doaj +1 more source
Вавиловский журнал генетики и селекции, 2022 Alkanmonooxygenase enzymes AlkB and Cyp153 are responsible for the aerobic degradation of n-alkanes of petroleum and petroleum products. To prove the usage of n-alkanes from oil and petroleum products by hydrocarbon- oxidizing bacteria isolated from ...
T. N. Shapiro +2 more
doaj +1 more source
Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
doaj +1 more source