Results 21 to 30 of about 6,174 (170)
Substrate specificities of bacterial and human AlkB proteins [PDF]
Nucleic Acids Research, 2004 Methylating agents introduce cytotoxic 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) residues into nucleic acids, and it was recently demonstrated that the Escherichia coli AlkB protein and two human homologues, hABH2 and hABH3, can remove these lesions from DNA by oxidative demethylation. Moreover, AlkB and hABH3 were also found to remove 1-meA
Pål Ø, Falnes +4 more
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Frontiers in Cell and Developmental Biology, 2021 The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu +8 more
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Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis
Frontiers in Physiology, 2022 Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase AlkB homolog H5 (ALKBH5), has recently been reported to be involved in several biological processes.
Cheng Tian +12 more
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Arab Journal of Basic and Applied Sciences, 2023 Thirty-four different soil Streptomyces isolates previously recovered from soils of different gas stations that were historically polluted with fuel oil for long time were analyzed for their ability to produce five different hydrolytic enzymes, as well ...
Ismail Saadoun +5 more
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Frontiers in Microbiology, 2014 Alkane degrading microorganisms play an important role for bioremediation of petrogenic contaminated environments. In this study, we investigated the effects of compost addition on the diversity of alkane monooxygenase gene (alkB) harboring bacteria in ...
Michael eSchloter
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Therapeutic potential of ALKB homologs for cardiovascular disease
Biomedicine & Pharmacotherapy, 2020 Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation.
Ming-Zhu, Xiao +5 more
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Scientific Reports, 2017 An unprecedented method for the efficient conversion of C3–C12 linear alkanes to their corresponding primary alcohols mediated by the membrane-bound alkane hydroxylase (AlkB) from Pseudomonas putida GPo1 is demonstrated. The X-ray absorption spectroscopy
Yi-Fang Tsai +8 more
doaj +1 more source
Structural and mechanistic studies of AlkB
The FASEB Journal, 2008 Recently, there has been rapid progress in understanding the molecular functions of DNA repair enzymes in the AlkB superfamily, which are present in many eubacteria and all higher eukaryotes. These enzymes have been demonstrated to catalyze direct repair of adenine and cytosine bases that have been alkylated on endocyclic nitrogen ...
John Francis Hunt +8 more
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Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues [PDF]
Journal of Biological Chemistry, 2005 Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde. In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have ...
Lee, Dong-Hyun +5 more
openaire +4 more sources
Microbiology Spectrum, 2022 Mycobacterium tuberculosis is a highly specialized human pathogen. The success of M. tuberculosis is due to its ability to replicate within host macrophages, resist host immune responses, and ultimately enter a persistent state during a latent ...
Haley Stokas +5 more
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