Results 1 to 10 of about 89 (84)
Molecular Oncology, 2023 Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Meng Xue
exaly +2 more sources
The biological function of demethylase ALKBH1 and its role in human diseases
HeliyonAlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong, Xu Zhengyang, Wenwen Chen
exaly +3 more sources
Scientific ReportsPreeclampsia (PE) is a pregnancy disease characterized by insufficient invasion and growth of trophoblast cells. adeno-associated virus encoding alkB homolog 1 (ALKBH1) is a demethylase in 5-methylcytosine (m5C) methylation modification.
Luwen Wang, Xiaohua Luo, Caili Zhang
exaly +2 more sources
ALKBH1: emerging biomarker and therapeutic target for cancer treatment
Discover OncologyAs neoplastic cells proliferate, disseminate, and infiltrate, they undergo substantial alterations in their epigenetic configuration. Among the pivotal enzymes implicated in this phenomenon is the AlkB family of demethylases, notably AlkB homolog 1 ...
Ming Zhu Xiao +5 more
exaly +2 more sources
The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma [PDF]
PeerJ, 2021 Background Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known.
Bi Peng, Yuanliang Yan, Zhijie Xu
doaj +2 more sources
ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. [PDF]
PLoS ONE, 2013 Potential roles of the abasic site lyase activity associated with AlkB homolog 1 (ALKBH1) were assessed by studies focusing on the two cellular processes that create abasic sites as intermediates: base excision repair and class switch recombination ...
Tina A Müller +3 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and mortality whereas the pathogenic mechanism remains largely elusive.
Liping Luo +9 more
doaj +1 more source
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. [PDF]
PLoS ONE, 2010 Escherichia coli AlkB is a 2-oxoglutarate- and iron-dependent dioxygenase that reverses alkylated DNA damage by oxidative demethylation. Mouse AlkB homolog 1 (Alkbh1) is one of eight members of the newly discovered family of mammalian dioxygenases.In the
Line M Nordstrand +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu +8 more
doaj +1 more source
Genome Biology, 2023 Background The Fe (II)- and α-ketoglutarate-dependent AlkB family dioxygenases are implicated in nucleotide demethylation. AlkB homolog1 (ALKBH1) is shown to demethylate DNA adenine methylation (6mA) preferentially from single-stranded or unpaired DNA ...
Qingxiao Jia +12 more
doaj +1 more source