Results 41 to 50 of about 139 (105)

TRMT10C promotes mitochondrial fission through transferrin receptor m1A methylation modification and aggravates the progression of atrial fibrillation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
TRMT10C promotes mitochondrial dynamics imbalance (excessive fission) by regulating TFRC m1A methylation modification, induces myocardial fibrosis, and exacerbates the progression of AF. Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia often accompanied by structural remodeling of the atria, particularly fibrosis, and disruption of ...
Nijina Li, Hao Zhang
wiley   +1 more source

Novel methylation mark and essential hypertension

Journal of Genetic Engineering and Biotechnology, 2022
Background Essential hypertension (EH) is an important risk factor for various cardiovascular, cerebral and renal disorders. It is a multi-factorial trait which occurs through complex interplay between genetic, epigenetic, and environmental factors. Even
Mayank Chaudhary
doaj   +1 more source

WTAP affects intracranial aneurysm progression by regulating m6A methylation modification

Open Medicine, 2023
Intracranial aneurysm (IA) is a type of cerebrovascular disease that mainly occurs in the circle of Willis. Abnormalities in RNA methylation at the N6-methyladenosine (m6A) site have been associated with numerous types of human diseases.
Yuan Xuesong, Bao Qing, Lu Bin, Xiang Chong, Hou Xiaoshan, Wei Wenfeng   +5 more
doaj   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

血清IGF2BP3与2型糖尿病的U型关联:一项中国人群横断面研究

Journal of Diabetes, 2023
Objective To clarify the expression of N6‐methyladenosine (m6A) modulators involved in the pathogenesis of type 2 diabetes mellitus (T2DM). We further explored the association of serum insulin‐like growth factor 2 mRNA‐binding proteins 3 (IGF2BP3) levels
Xiaoying Wu, Wei Wang, Shujin Fan, Lili You, Feng Li, Xiaoyun Zhang, Hongshi Wu, Juying Tang, Yiqin Qi, Wanting Feng, Li Yan, Meng Ren   +11 more
doaj   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization

Frontiers in Cardiovascular Medicine, 2022
ObjectivesThis study aimed to identify key AAA-related m1A RNA methylation regulators and their association with immune infiltration in AAA. Furthermore, we aimed to explore the mechanism that m1A regulators modulate the functions of certain immune cells
Yihao Wu, Deying Jiang, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaoxu Zhang, Ce Bian, Chen Chen, Shuixin Li, Yuhan Yin, Dittmar Böckler, Jian Zhang, Yanshuo Han   +12 more
doaj   +1 more source

Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen, Jiawei Mao, Lin Xu, Linbei Lu, Yajuan Hao   +4 more
wiley   +1 more source

Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression

Liver Research, 2023
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease worldwide, with an increasing incidence rate.
Jinyong He, Cuicui Xiao, Cuiping Li, Fan Yang, Cong Du   +4 more
doaj   +1 more source

GPRC5B Identified by m5C meRIP‐Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2‐Mediated RNA Methylation

Cancer Science, Volume 117, Issue 5, Page 1322-1332, May 2026.
We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen, Min Yang, Xiaoxiao Liang, Zhiqiang Yang, Wulan Mai, Yuyang Wang, Yushen Lu, Ruimin Wang, Yuanhang Han, Yuanlong Xie, Lin Cai   +10 more
wiley   +1 more source